气候变化领域集成服务门户(CCPortal): Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells

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DOI	10.1073/pnas.2014157118
	Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells
	Rogers S.; Rozman P.A.; Valero M.; Doyle W.K.; Buzsáki G.
发表日期	2021
ISSN	00278424
卷号	118 期号:2
英文摘要	How do firing patterns in a cortical circuit change when inhibitory neurons are excited? We virally expressed an excitatory designer receptor exclusively activated by a designer drug (Gq-DREADD) in all inhibitory interneuron types of the CA1 region of the hippocampus in the rat. While clozapine N-oxide (CNO) activation of interneurons suppressed firing of pyramidal cells, unexpectedly the majority of interneurons also decreased their activity. CNO-induced inhibition decreased over repeated sessions, which we attribute to long-term synaptic plasticity between interneurons and pyramidal cells. Individual interneurons did not display sustained firing but instead transiently enhanced their activity, interleaved with suppression of others. The power of the local fields in the theta band was unaffected, while power at higher frequencies was attenuated, likely reflecting reduced pyramidal neuron spiking. The incidence of sharp wave ripples decreased but the surviving ripples were associated with stronger population firing compared with the control condition. These findings demonstrate that DREADD activation of interneurons brings about both short-term and long-term circuit reorganization, which should be taken into account in the interpretation of chemogenic effects on behavior. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	DREADDs; Hippocampus; Interneurons; Perturbation; Sharp wave ripples
语种	英语
scopus关键词	clozapine n oxide; action potential; adult; animal experiment; animal tissue; Article; controlled study; firing rate; hippocampal CA1 region; interneuron; local field potential; male; nerve cell plasticity; nonhuman; nonREM sleep; priority journal; pyramidal nerve cell; rat; stratum radiatum; theta rhythm
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181088
作者单位	Neuroscience Institute, Langone Medical Center, New York University, New York, NY 10016, United States; Department of Neurosurgery, Langone Medical Center, New York University, New York, NY 10016, United States; Department of Neurology, Langone Medical Center, New York University, New York, NY 10016, United States; Center for Neural Science, New York University, New York, NY 10003, United States
推荐引用方式 GB/T 7714	Rogers S.,Rozman P.A.,Valero M.,et al. Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells[J],2021,118(2).
APA	Rogers S.,Rozman P.A.,Valero M.,Doyle W.K.,&Buzsáki G..(2021).Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells.Proceedings of the National Academy of Sciences of the United States of America,118(2).
MLA	Rogers S.,et al."Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells".Proceedings of the National Academy of Sciences of the United States of America 118.2(2021).