气候变化领域集成服务门户(CCPortal): Astrocytic cAMP modulates memory via synaptic plasticity

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DOI	10.1073/PNAS.2016584118
	Astrocytic cAMP modulates memory via synaptic plasticity
	Zhou Z.; Okamoto K.; Onodera J.; Hiragi T.; Andoh M.; Ikawa M.; Tanaka K.F.; Ikegaya Y.; Koyama R.
发表日期	2021
ISSN	00278424
卷号	118 期号:3
英文摘要	Astrocytes play a key role in brain homeostasis and functions such as memory. Specifically, astrocytes express multiple receptors that transduce signals via the second messenger cAMP. However, the involvement of astrocytic cAMP in animal behavior and the underlying glial-neuronal interactions remains largely unknown. Here, we show that an increase in astrocytic cAMP is sufficient to induce synaptic plasticity and modulate memory. We developed a method to increase astrocytic cAMP levels in vivo using photoactivated adenylyl cyclase and found that increased cAMP in hippocampal astrocytes at different time points facilitated memory formation but interrupted memory retention via NMDA receptor-dependent plasticity. Furthermore, we found that the cAMP-induced modulation of memory was mediated by the astrocyte-neuron lactate shuttle. Thus, our study unveils a role of astrocytic cAMP in brain function by providing a tool to modulate astrocytic cAMP in vivo. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Astrocyte; CAMP; Memory; PAC; Synapse
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181008
作者单位	Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-8654, Japan; Animal Resource Center for Infectious Diseases, Research Institute for Microbial Diseases, Suita, Osaka, 565-0871, Japan; Department of Neuropsychiatry, School of Medicine, Keio University, Shinjuku, Tokyo, 160-8582, Japan; Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita, Osaka, 565-0871, Japan; Institute for AI and Beyond, University of Tokyo, Tokyo, 113-0033, Japan
推荐引用方式 GB/T 7714	Zhou Z.,Okamoto K.,Onodera J.,et al. Astrocytic cAMP modulates memory via synaptic plasticity[J],2021,118(3).
APA	Zhou Z..,Okamoto K..,Onodera J..,Hiragi T..,Andoh M..,...&Koyama R..(2021).Astrocytic cAMP modulates memory via synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America,118(3).
MLA	Zhou Z.,et al."Astrocytic cAMP modulates memory via synaptic plasticity".Proceedings of the National Academy of Sciences of the United States of America 118.3(2021).