气候变化领域集成服务门户(CCPortal): The natural axis of transmitter receptor distribution in the human cerebral cortex

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DOI	10.1073/PNAS.2020574118
	The natural axis of transmitter receptor distribution in the human cerebral cortex
	Goulas A.; Changeux J.-P.; Wagstyl K.; Amunts K.; Palomero-Gallagher N.; Hilgetag C.C.
发表日期	2021
ISSN	00278424
卷号	118 期号:3
英文摘要	Transmitter receptors constitute a key component of the molecular machinery for intercellular communication in the brain. Recent efforts have mapped the density of diverse transmitter receptors across the human cerebral cortex with an unprecedented level of detail. Here, we distill these observations into key organizational principles. We demonstrate that receptor densities form a natural axis in the human cerebral cortex, reflecting decreases in differentiation at the level of laminar organization and a sensory-to-association axis at the functional level. Along this natural axis, key organizational principles are discerned: progressive molecular diversity (increase of the diversity of receptor density); excitation/inhibition (increase of the ratio of excitatory-to-inhibitory receptor density); and mirrored, orderly changes of the density of ionotropic and metabotropic receptors. The uncovered natural axis formed by the distribution of receptors aligns with the axis that is formed by other dimensions of cortical organization, such as the myelo- and cytoarchitectonic levels. Therefore, the uncovered natural axis constitutes a unifying organizational feature linking multiple dimensions of the cerebral cortex, thus bringing order to the heterogeneity of cortical organization. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cortical organization; Molecular diversity; Unifying principles
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181005
作者单位	Institute of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany; Communications Cellulaires, Collège de France, Paris, 75005, France; CNRS UMR 3571, Institut Pasteur, Paris, 75724, France; McGill Centre for Integrative Neuroscience, Montréal Neurological Institute, Montréal, QC H3A 2B4, Canada; Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, United Kingdom; Wellcome Trust Centre for Neuroimaging, University College London, London, WC1N 3AR, United Kingdom; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, 52425, Germany; C. and O. Vogt Institute for Brain Research, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, 40225, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical Faculty, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, 52074, Germany; Jülich Aachen Research Alliance (JARA)-Translational Brain Medicine, Aachen, Germany; De...
推荐引用方式 GB/T 7714	Goulas A.,Changeux J.-P.,Wagstyl K.,et al. The natural axis of transmitter receptor distribution in the human cerebral cortex[J],2021,118(3).
APA	Goulas A.,Changeux J.-P.,Wagstyl K.,Amunts K.,Palomero-Gallagher N.,&Hilgetag C.C..(2021).The natural axis of transmitter receptor distribution in the human cerebral cortex.Proceedings of the National Academy of Sciences of the United States of America,118(3).
MLA	Goulas A.,et al."The natural axis of transmitter receptor distribution in the human cerebral cortex".Proceedings of the National Academy of Sciences of the United States of America 118.3(2021).