气候变化领域集成服务门户(CCPortal): Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation

CCPortal

DOI	10.1073/pnas.2019097118
	Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation
	Skopelja-Gardner S.; Tai J.; Sun X.; Tanaka L.; Kuchenbecker J.A.; Snyder J.M.; Kubes P.; Mustelin T.; Elkon K.B.
发表日期	2021
ISSN	00278424
卷号	118 期号:3
英文摘要	Photosensitivity to ultraviolet (UV) light affects up to ∼80% of lupus patients. Sunlight exposure can exacerbate local as well as systemic manifestations of lupus, including nephritis, by mechanisms that are poorly understood. Here, we report that acute skin exposure to UV light triggers a neutrophil-dependent injury response in the kidney characterized by upregulated expression of endothelial adhesion molecules as well as inflammatory and injury markers associated with transient proteinuria. We showed that UV light stimulates neutrophil migration not only to the skin but also to the kidney in an IL-17A–dependent manner. Using a photoactivatable lineage tracing approach, we observed that a subset of neutrophils found in the kidney had transited through UV light–exposed skin, suggesting reverse transmigration. Besides being required for the renal induction of genes encoding mediators of inflammation (vcam-1, s100A9, and Il-1b) and injury (lipocalin-2 and kim-1), neutrophils significantly contributed to the kidney type I interferon signature triggered by UV light. Together, these findings demonstrate that neutrophils mediate subclinical renal inflammation and injury following skin exposure to UV light. Of interest, patients with lupus have subpopulations of blood neutrophils and low-density granulocytes with similar phenotypes to reverse transmigrating neutrophils observed in the mice post-UV exposure, suggesting that these cells could have transmigrated from inflamed tissue, such as the skin. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	UV light \| neutrophil migration \| kidney \| inflammation
语种	英语
scopus关键词	cell adhesion molecule; interferon; interleukin 17; animal cell; animal experiment; animal model; animal tissue; Article; cell migration; controlled study; female; gene; interleukin 1b gene; kidney injury; kim 1 gene; light exposure; lipocalin 2 gene; male; mouse; nephritis; neutrophil; nonhuman; photosensitivity; priority journal; protein expression; proteinuria; skin; ultraviolet radiation; upregulation; vcam 1 gene
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180988
作者单位	Division of Rheumatology, University of Washington, Seattle, WA 98195, United States; Department of Ophthalmology, University of Washington, Seattle, WA 98195, United States; Department of Comparative Medicine, University of Washington, Seattle, WA 98195, United States; Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 1N4, Canada; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98195, United States; Department of Immunology, University of Washington, Seattle, WA 98195, United States
推荐引用方式 GB/T 7714	Skopelja-Gardner S.,Tai J.,Sun X.,et al. Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation[J],2021,118(3).
APA	Skopelja-Gardner S..,Tai J..,Sun X..,Tanaka L..,Kuchenbecker J.A..,...&Elkon K.B..(2021).Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation.Proceedings of the National Academy of Sciences of the United States of America,118(3).
MLA	Skopelja-Gardner S.,et al."Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation".Proceedings of the National Academy of Sciences of the United States of America 118.3(2021).