气候变化领域集成服务门户(CCPortal): Environment-based object values learned by local network in the striatum tail

CCPortal

DOI	10.1073/pnas.2013623118
	Environment-based object values learned by local network in the striatum tail
	Kunimatsu J.; Yamamoto S.; Maeda K.; Hikosaka O.
发表日期	2021
ISSN	00278424
卷号	118 期号:4
英文摘要	Basal ganglia contribute to object-value learning, which is critical for survival. The underlying neuronal mechanism is the association of each object with its rewarding outcome. However, object values may change in different environments and we then need to choose different objects accordingly. The mechanism of this environment-based value learning is unknown. To address this question, we created an environment-based value task in which the value of each object was reversed depending on the two scene-environments (X and Y). After experiencing this task repeatedly, the monkeys became able to switch the choice of object when the scene-environment changed unexpectedly. When we blocked the inhibitory input from fast-spiking interneurons (FSIs) to medium spiny projection neurons (MSNs) in the striatum tail by locally injecting IEM-1460, the monkeys became unable to learn scene-selective object values. We then studied the mechanism of the FSI-MSN connection. Before and during this learning, FSIs responded to the scenes selectively, but were insensitive to object values. In contrast, MSNs became able to discriminate the objects (i.e., stronger response to good objects), but this occurred clearly in one of the two scenes (X or Y). This was caused by the scene-selective inhibition by FSI. As a whole, MSNs were divided into two groups that were sensitive to object values in scene X or in scene Y. These data indicate that the local network of striatum tail controls the learning of object values that are selective to the scene-environment. This mechanism may support our flexible switching behavior in various environments. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Local network; Primate; Saccade; Scene-environment; Striatum tail
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180874
作者单位	Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD 20892, United States; Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8577, Japan; Transborder Medical Research Center, University of Tsukuba, Tsukuba, 305-8577, Japan; Integrative Neuroscience, Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, 305-8568, Japan
推荐引用方式 GB/T 7714	Kunimatsu J.,Yamamoto S.,Maeda K.,et al. Environment-based object values learned by local network in the striatum tail[J],2021,118(4).
APA	Kunimatsu J.,Yamamoto S.,Maeda K.,&Hikosaka O..(2021).Environment-based object values learned by local network in the striatum tail.Proceedings of the National Academy of Sciences of the United States of America,118(4).
MLA	Kunimatsu J.,et al."Environment-based object values learned by local network in the striatum tail".Proceedings of the National Academy of Sciences of the United States of America 118.4(2021).