气候变化领域集成服务门户(CCPortal): The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype

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DOI	10.1073/pnas.2014634118
	The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype
	Margres M.J.; Rautsaw R.M.; Strickland J.L.; Mason A.J.; Schramer T.D.; Hofmann E.P.; Stiers E.; Ellsworth S.A.; Nystrom G.S.; Hogan M.P.; Bartlett D.A.; Colston T.J.; Gilbert D.M.; Rokyta D.R.; Parkinson C.L.
发表日期	2021
ISSN	00278424
卷号	118 期号:4
英文摘要	Variation in gene regulation is ubiquitous, yet identifying the mechanisms producing such variation, especially for complex traits, is challenging. Snake venoms provide a model system for studying the phenotypic impacts of regulatory variation in complex traits because of their genetic tractability. Here, we sequence the genome of the Tiger Rattlesnake, which possesses the simplest and most toxic venom of any rattlesnake species, to determine whether the simple venom phenotype is the result of a simple genotype through gene loss or a complex genotype mediated through regulatory mechanisms. We generate the most contiguous snake-genome assembly to date and use this genome to show that gene loss, chromatin accessibility, and methylation levels all contribute to the production of the simplest, most toxic rattlesnake venom. We provide the most complete characterization of the venom gene-regulatory network to date and identify key mechanisms mediating phenotypic variation across a polygenic regulatory network. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Chromatin; Gene regulation; Genotype–phenotype; Methylation
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180848
作者单位	Department of Biological Sciences, Clemson University, Clemson, SC 29634, United States; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, United States; Department of Integrative Biology, University of South Florida, Tampa, FL 33620, United States; Department of Biology, University of South Alabama, Mobile, AL 36688, United States; Department of Biological Science, Florida State University, Tallahassee, FL 32306, United States; Department of Forestry and Environmental Conservation, Clemson University, Clemson, SC 29634, United States
推荐引用方式 GB/T 7714	Margres M.J.,Rautsaw R.M.,Strickland J.L.,et al. The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype[J],2021,118(4).
APA	Margres M.J..,Rautsaw R.M..,Strickland J.L..,Mason A.J..,Schramer T.D..,...&Parkinson C.L..(2021).The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype.Proceedings of the National Academy of Sciences of the United States of America,118(4).
MLA	Margres M.J.,et al."The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype".Proceedings of the National Academy of Sciences of the United States of America 118.4(2021).