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DOI	10.1073/pnas.2022350118
	Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype
	Hanemaaijer E.S.; Margaritis T.; Sanders K.; Bos F.L.; Candelli T.; Al-Saati H.; van Noesel M.M.; Meyer-Wentrup F.A.G.; van de Wetering M.; Holstege F.C.P.; Clevers H.
发表日期	2021
ISSN	00278424
卷号	118 期号:5
英文摘要	Neuroblastoma is the most common extracranial solid tumor and accounts for ∼10% of pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is generally accepted that neuroblastoma derives from the neural crest and should thus be considered an embryonal malignancy. About 50% of primary neuroblastoma tumors arise in the adrenal gland. Here, we present an atlas of the developing mouse adrenal gland at a single-cell level. Five main cell cluster groups (medulla, cortex, endothelial, stroma, and immune) make up the mouse adrenal gland during fetal development. The medulla group, which is of neural crest origin, is further divided into seven clusters. Of interest is the Schwann cell precursor (“SCP”) and the “neuroblast” cluster, a highly cycling cluster that shares markers with sympathoblasts. The signature of the medullary SCP cluster differentiates neuroblastoma patients based on disease phenotype: The SCP signature score anticorrelates with ALK and MYCN expression, two indicators of poor prognosis. Furthermore, a high SCP signature score is associated with better overall survival rates. This study provides an insight into the developing adrenal gland and introduces the SCP gene signature as being of interest for further research in understanding neuroblastoma phenotype. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Adrenal gland; Human pathology; Neuroblastoma; Single-cell RNA sequencing
语种	英语
scopus关键词	anaplastic lymphoma kinase; N Myc proto oncogene protein; adrenal cell; adrenal cortex cell; adrenal medullary cell; animal cell; animal experiment; animal tissue; Article; cancer prognosis; cell differentiation; cell function; cohort analysis; controlled study; disease association; endothelium cell; fetus development; gene function; human; immunocompetent cell; neural crest; neuroblastoma; neuroblastoma cell; nonhuman; overall survival; phenotype; priority journal; protein expression; Schwann cell; single cell analysis; stroma cell
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180838
作者单位	Oncode Institute, Princess Máxima Center for Pediatric Oncology, Utrecht, 3584 CS, Netherlands; Princess Máxima Center for Pediatric Oncology, Utrecht, 3584 CS, Netherlands; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, 3584 CM, Netherlands; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University Medical Center, Utrecht, 3584 CT, Netherlands
推荐引用方式 GB/T 7714	Hanemaaijer E.S.,Margaritis T.,Sanders K.,et al. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype[J],2021,118(5).
APA	Hanemaaijer E.S..,Margaritis T..,Sanders K..,Bos F.L..,Candelli T..,...&Clevers H..(2021).Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.Proceedings of the National Academy of Sciences of the United States of America,118(5).
MLA	Hanemaaijer E.S.,et al."Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype".Proceedings of the National Academy of Sciences of the United States of America 118.5(2021).