气候变化领域集成服务门户(CCPortal): Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin

CCPortal

DOI	10.1073/pnas.2020398118
	Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin
	Kwon K.; Wang H.; Lim J.; Chun K.S.; Jang H.; Yoo I.; Wu D.; Chen A.J.; Gu C.G.; Lipschultz L.; Kim J.U.; Kim J.; Jeong H.; Luan H.; Park Y.; Su C.-J.; Ishida Y.; Madhvapathy S.R.; Ikoma A.; Kwak J.W.; Yang D.S.; Banks A.; Xu S.; Huang Y.; Chang J.-K.; Rogers J.A.
发表日期	2021
ISSN	00278424
卷号	118 期号:5
英文摘要	Precise, quantitative measurements of the hydration status of skin can yield important insights into dermatological health and skin structure and function, with additional relevance to essential processes of thermoregulation and other features of basic physiology. Existing tools for determining skin water content exploit surrogate electrical assessments performed with bulky, rigid, and expensive instruments that are difficult to use in a repeatable manner. Recent alternatives exploit thermal measurements using soft wireless devices that adhere gently and noninvasively to the surface of the skin, but with limited operating range (∼1 cm) and high sensitivity to subtle environmental fluctuations. This paper introduces a set of ideas and technologies that overcome these drawbacks to enable high-speed, robust, long-range automated measurements of thermal transport properties via a miniaturized, multisensor module controlled by a long-range (∼10 m) Bluetooth Low Energy system on a chip, with a graphical user interface to standard smartphones. Soft contact to the surface of the skin, with almost zero user burden, yields recordings that can be quantitatively connected to hydration levels of both the epidermis and dermis, using computational modeling techniques, with high levels of repeatability and insensitivity to ambient fluctuations in temperature. Systematic studies of polymers in layered configurations similar to those of human skin, of porcine skin with known levels of hydration, and of human subjects with benchmarks against clinical devices validate the measurement approach and associated sensor hardware. The results support capabilities in characterizing skin barrier function, assessing severity of skin diseases, and evaluating cosmetic and medication efficacy, for use in the clinic or in the home. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Biomedical devices; Diagnostics; Flexible electronics; Health monitoring; Wireless electronics
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180827
作者单位	Querrey-Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, United States; School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea; Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, United States; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, United States; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, United States; Wearifi Inc., Evanston, IL 60201, United States; Electrical and Computer Engineering, University of Texas at Austin, Austin, TX 78712, United States; Department of Electrical and Computer Engineering, University of Wisconsin, Madison, WI 53706, United States; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, United States; School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, South Korea; School of Advanced Materials Sc...
推荐引用方式 GB/T 7714	Kwon K.,Wang H.,Lim J.,et al. Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin[J],2021,118(5).
APA	Kwon K..,Wang H..,Lim J..,Chun K.S..,Jang H..,...&Rogers J.A..(2021).Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin.Proceedings of the National Academy of Sciences of the United States of America,118(5).
MLA	Kwon K.,et al."Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin".Proceedings of the National Academy of Sciences of the United States of America 118.5(2021).