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DOI	10.1073/pnas.2012327118
	Anomalous influenza seasonality in the United States and the emergence of novel influenza B viruses
	Borchering R.K.; Gunning C.E.; Gokhale D.V.; Weedop K.B.; Saeidpour A.; Brett T.S.; Rohani P.
发表日期	2021
ISSN	00278424
卷号	118 期号:5
英文摘要	The 2019/2020 influenza season in the United States began earlier than any season since the 2009 H1N1 pandemic, with an increase in influenza-like illnesses observed as early as August. Also noteworthy was the numerical domination of influenza B cases early in this influenza season, in contrast to their typically later peak in the past. Here, we dissect the 2019/2020 influenza season not only with regard to its unusually early activity, but also with regard to the relative dynamics of type A and type B cases. We propose that the recent expansion of a novel influenza B/Victoria clade may be associated with this shift in the composition and kinetics of the influenza season in the United States. We use epidemiological transmission models to explore whether changes in the effective reproduction number or short-term cross-immunity between these viruses can explain the dynamics of influenza A and B seasonality. We find support for an increase in the effective reproduction number of influenza B, rather than support for cross-type immunity-driven dynamics. Our findings have clear implications for optimal vaccination strategies. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Epidemiological models; Genetic diversity; Influenza; Statistical inference; Viral interference
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180820
作者单位	Odum School of Ecology, University of Georgia, Athens, GA 30602, United States; Center for the Ecology of Infectious Diseases, University of Georgia, Athens, GA 30602, United States; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, United States; Department of Infectious Diseases, University of Georgia, Athens, GA 30602, United States
推荐引用方式 GB/T 7714	Borchering R.K.,Gunning C.E.,Gokhale D.V.,et al. Anomalous influenza seasonality in the United States and the emergence of novel influenza B viruses[J],2021,118(5).
APA	Borchering R.K..,Gunning C.E..,Gokhale D.V..,Weedop K.B..,Saeidpour A..,...&Rohani P..(2021).Anomalous influenza seasonality in the United States and the emergence of novel influenza B viruses.Proceedings of the National Academy of Sciences of the United States of America,118(5).
MLA	Borchering R.K.,et al."Anomalous influenza seasonality in the United States and the emergence of novel influenza B viruses".Proceedings of the National Academy of Sciences of the United States of America 118.5(2021).