气候变化领域集成服务门户(CCPortal): Lipopeptide-mediated bacterial interaction enables cooperative predator defense

CCPortal

DOI	10.1073/pnas.2013759118
	Lipopeptide-mediated bacterial interaction enables cooperative predator defense
	Zhang S.; Mukherji R.; Chowdhury S.; Reimer L.; Stallforth P.
发表日期	2021
ISSN	00278424
卷号	118 期号:6
英文摘要	Bacteria are inherently social organisms whose actions should ideally be studied within an interactive ecological context. We show that the exchange and modification of natural products enables two unrelated bacteria to defend themselves against a common predator. Amoebal predation is a major cause of death in soil bacteria and thus it exerts a strong selective pressure to evolve defensive strategies. A systematic analysis of binary combinations of coisolated bacteria revealed strains that were individually susceptible to predation but together killed their predator. This cooperative defense relies on a Pseudomonas species producing syringafactin, a lipopeptide, which induces the production of peptidases in a Paenibacillus strain. These peptidases then degrade the innocuous syringafactin into compounds, which kill the predator. A combination of bioprospecting, coculture experiments, genome modification, and transcriptomics unravel this novel natural product-based defense strategy. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Amoebae; Cooperative defense; Lipopeptides; Natural products; Pseudomonas
语种	英语
scopus关键词	lipopeptide; natural product; peptidase; protein syringafactin; unclassified drug; Article; bacterial strain; bacterium isolation; bioprospecting; coculture; controlled study; DNA modification; microbial interaction; nonhuman; Paenibacillus; predation; priority journal; protein synthesis; Pseudomonas; transcriptomics
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180768
作者单位	Department of Paleobiotechnology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, 07745, Germany
推荐引用方式 GB/T 7714	Zhang S.,Mukherji R.,Chowdhury S.,et al. Lipopeptide-mediated bacterial interaction enables cooperative predator defense[J],2021,118(6).
APA	Zhang S.,Mukherji R.,Chowdhury S.,Reimer L.,&Stallforth P..(2021).Lipopeptide-mediated bacterial interaction enables cooperative predator defense.Proceedings of the National Academy of Sciences of the United States of America,118(6).
MLA	Zhang S.,et al."Lipopeptide-mediated bacterial interaction enables cooperative predator defense".Proceedings of the National Academy of Sciences of the United States of America 118.6(2021).