气候变化领域集成服务门户(CCPortal): Neural correlates of goal-directed and non-goal-directed movements

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DOI	10.1073/pnas.2006372118
	Neural correlates of goal-directed and non-goal-directed movements
	Sendhilnathan N.; Basu D.; Goldberg M.E.; Schall J.D.; Murthy A.
发表日期	2021
ISSN	00278424
卷号	118 期号:6
英文摘要	What are the cortical neural correlates that distinguish goal-directed and non-goal-directed movements? We investigated this question in the monkey frontal eye field (FEF), which is implicated in voluntary control of saccades. Here, we compared FEF activity associated with goal-directed (G) saccades and non-goal-directed (nG) saccades made by the monkey. Although the FEF neurons discharged before these nG saccades, there were three major differences in the neural activity: First, the variability in spike rate across trials decreased only for G saccades. Second, the local field potential beta-band power decreased during G saccades but did not change during nG saccades. Third, the time from saccade direction selection to the saccade onset was significantly longer for G saccades compared with nG saccades. Overall, our results reveal unexpected differences in neural signatures for G versus nG saccades in a brain area that has been implicated selectively in voluntary control. Taken together, these data add critical constraints to the way we think about saccade generation in the brain. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Beta; Frontal eye field; Saccade; Variability
语种	英语
scopus关键词	animal experiment; article; controlled study; frontal eye field; Haplorhini; local field potential; nerve cell; nonhuman; saccadic eye movement; spike
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180726
作者单位	Columbia University, New York, NY 10027, United States; Department of Neuroscience, Columbia University, New York, NY 10027, United States; Mahoney-Keck Center for Brain and Behavior Research, Columbia University, New York, NY 10027, United States; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, United States; New York State Psychiatric Institute, New York, NY 10032, United States; Center for Neuroscience, Indian Institute of Science, Bangalore, 560012, India; Kavli Institute for Brain Science, Columbia University, New York, NY 10027, United States; Department of Neurology, Psychiatry, and Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, United States; Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN 37235, United States; Center for Integrative and Cognitive Neuroscience, Department of Psychology, Vanderbilt University, Nashville, TN 37235, United States
推荐引用方式 GB/T 7714	Sendhilnathan N.,Basu D.,Goldberg M.E.,et al. Neural correlates of goal-directed and non-goal-directed movements[J],2021,118(6).
APA	Sendhilnathan N.,Basu D.,Goldberg M.E.,Schall J.D.,&Murthy A..(2021).Neural correlates of goal-directed and non-goal-directed movements.Proceedings of the National Academy of Sciences of the United States of America,118(6).
MLA	Sendhilnathan N.,et al."Neural correlates of goal-directed and non-goal-directed movements".Proceedings of the National Academy of Sciences of the United States of America 118.6(2021).