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DOI	10.1073/pnas.2015675118
	The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1
	Zhang P.; Katzaroff A.J.; Buttitta L.A.; Ma Y.; Jiang H.; Nickerson D.W.; Øvrebø J.I.; Edgar B.A.
发表日期	2021
ISSN	00278424
卷号	118 期号:7
英文摘要	Using a gain-of-function screen in Drosophila, we identified the Krüppel-like factor Cabut (Cbt) as a positive regulator of cell cycle gene expression and cell proliferation. Enforced cbt expression is sufficient to induce an extra cell division in the differentiating fly wing or eye, and also promotes intestinal stem cell divisions in the adult gut. Although inappropriate cell proliferation also results from forced expression of the E2f1 transcription factor or its target, Cyclin E, Cbt does not increase E2F1 or Cyclin E activity. Instead, Cbt regulates a large set of E2F1 target genes independently of E2F1, and our data suggest that Cbt acts via distinct binding sites in target gene promoters. Although Cbt was not required for cell proliferation during wing or eye development, Cbt is required for normal intestinal stem cell divisions in the midgut, which expresses E2F1 at relatively low levels. The E2F1-like functions of Cbt identify a distinct mechanism for cell cycle regulation that may be important in certain normal cell cycles, or in cells that cycle inappropriately, such as cancer cells. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cabut (Cbt) \| cell cycle exit \| E2F1 \| intestinal stem cell (ISC) \| proliferation
语种	英语
scopus关键词	cyclin E; kruppel like factor; protein Cabut; transcription factor E2F1; unclassified drug; adult; Article; binding site; cancer cell; cbt gene; cell cycle regulation; cell differentiation; cell division; cell proliferation; controlled study; Cyclin E gene; Drosophila; eye development; female; gain of function mutation; gene control; gene expression; gene identification; gene overexpression; gene targeting; genetic screening; intestinal stem cell; midgut; nonhuman; priority journal; promoter region; protein analysis; protein function
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180658
作者单位	Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, United States; Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, United States; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, United States; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States
推荐引用方式 GB/T 7714	Zhang P.,Katzaroff A.J.,Buttitta L.A.,et al. The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1[J],2021,118(7).
APA	Zhang P..,Katzaroff A.J..,Buttitta L.A..,Ma Y..,Jiang H..,...&Edgar B.A..(2021).The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1.Proceedings of the National Academy of Sciences of the United States of America,118(7).
MLA	Zhang P.,et al."The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1".Proceedings of the National Academy of Sciences of the United States of America 118.7(2021).