气候变化领域集成服务门户(CCPortal): Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons

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DOI	10.1073/pnas.2019295118
	Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons
	Wang J.; Li J.; Yang Q.; Xie Y.-K.; Wen Y.-L.; Xu Z.-Z.; Li Y.; Xu T.; Wu Z.-Y.; Duan S.; Xu H.
发表日期	2021
ISSN	00278424
卷号	118 期号:7
英文摘要	Sociability is fundamental for our daily life and is compromised in major neuropsychiatric disorders. However, the neuronal circuit mechanisms underlying prosocial behavior are still elusive. Here we identify a causal role of the basal forebrain (BF) in the control of prosocial behavior via inhibitory projections that disinhibit the midbrain ventral tegmental area (VTA) dopamine (DA) neurons. Specifically, BF somatostatin-positive (SST) inhibitory neurons were robustly activated during social interaction. Optogenetic inhibition of these neurons in BF or their axon terminals in the VTA largely abolished social preference. Electrophysiological examinations further revealed that SST neurons predominantly targeted VTA GABA neurons rather than DA neurons. Consistently, optical inhibition of SST neuron axon terminals in the VTA decreased DA release in the nucleus accumbens during social interaction, confirming a disinhibitory action. These data reveal a previously unappreciated function of the BF in prosocial behavior through a disinhibitory circuitry connected to the brain’s reward system. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Basal forebrain \| disinhibition \| social interaction \| ventral tegmental area
语种	英语
scopus关键词	4 aminobutyric acid; dopamine; somatostatin; animal experiment; animal tissue; Article; basal forebrain; brain function; cell activation; dopamine release; dopaminergic nerve cell; male; mesencephalon; mouse; nerve ending; nervous system electrophysiology; nonhuman; nucleus accumbens; optogenetics; priority journal; prosocial behavior; reward; social interaction; ventral tegmentum
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180637
作者单位	Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China; Department ofNeurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE FrontierScience Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking-TsinghuaCenter for Life Sciences, Beijing, 100871, China; Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong UniversitySchool of Medicine, Shanghai, 200025, China
推荐引用方式 GB/T 7714	Wang J.,Li J.,Yang Q.,et al. Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons[J],2021,118(7).
APA	Wang J..,Li J..,Yang Q..,Xie Y.-K..,Wen Y.-L..,...&Xu H..(2021).Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons.Proceedings of the National Academy of Sciences of the United States of America,118(7).
MLA	Wang J.,et al."Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons".Proceedings of the National Academy of Sciences of the United States of America 118.7(2021).