气候变化领域集成服务门户(CCPortal): Placental genomic risk scores and early neurodevelopmental outcomes

CCPortal

DOI	10.1073/pnas.2019789118
	Placental genomic risk scores and early neurodevelopmental outcomes
	Ursini G.; Punzi G.; Langworthy B.W.; Chen Q.; Xia K.; Cornea E.A.; Goldman B.D.; Styner M.A.; Knickmeyer R.C.; Gilmore J.H.; Weinberger D.R.
发表日期	2021
ISSN	00278424
卷号	118 期号:7
英文摘要	Tracing the early paths leading to developmental disorders is critical for prevention. In previous work, we detected an interaction between genomic risk scores for schizophrenia (GRSs) and early-life complications (ELCs), so that the liability of the disorder explained by genomic risk was higher in the presence of a history of ELCs, compared with its absence. This interaction was specifically driven by loci harboring genes highly expressed in placentae from normal and complicated pregnancies [G. Ursini et al., Nat. Med. 24, 792–801 (2018)]. Here, we analyze whether fractionated genomic risk scores for schizophrenia and other developmental disorders and traits, based on placental gene-expression loci (PlacGRSs), are linked with early neurodevelopmental outcomes in individuals with a history of ELCs. We found that schizophrenia’s PlacGRSs are negatively associated with neonatal brain volume in singletons and offspring of multiple pregnancies and, in singletons, with cognitive development at 1 y and, less strongly, at 2 y, when cognitive scores become more sensitive to other factors. These negative associations are stronger in males, found only with GRSs fractionated by placental gene expression, and not found in PlacGRSs for other developmental disorders and traits. The relationship of PlacGRSs with brain volume persists as an anlage of placenta biology in adults with schizophrenia, again selectively in males. Higher placental genomic risk for schizophrenia, in the presence of ELCs and particularly in males, alters early brain growth and function, defining a potentially reversible neurodevelopmen. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Schizophrenia \| developmental trajectories
语种	英语
scopus关键词	adult; Article; brain function; brain growth; brain size; child; cognitive development; controlled study; developmental disorder; female; gene expression; gene locus; genetic risk score; genotype; human; infant; longitudinal study; major clinical study; male; mental disease; multiple birth offspring; multiple pregnancy; newborn; placenta; prediction; priority journal; schizophrenia; school child; sex difference
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180626
作者单位	Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, United States; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Frank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, United States; Institute for Quantitative Health Sciences and Engineering, Michiga...
推荐引用方式 GB/T 7714	Ursini G.,Punzi G.,Langworthy B.W.,et al. Placental genomic risk scores and early neurodevelopmental outcomes[J],2021,118(7).
APA	Ursini G..,Punzi G..,Langworthy B.W..,Chen Q..,Xia K..,...&Weinberger D.R..(2021).Placental genomic risk scores and early neurodevelopmental outcomes.Proceedings of the National Academy of Sciences of the United States of America,118(7).
MLA	Ursini G.,et al."Placental genomic risk scores and early neurodevelopmental outcomes".Proceedings of the National Academy of Sciences of the United States of America 118.7(2021).