气候变化领域集成服务门户(CCPortal): Peripheral sensory stimulation elicits global slow waves by recruiting somatosensory cortex bilaterally

CCPortal

DOI	10.1073/pnas.2021252118
	Peripheral sensory stimulation elicits global slow waves by recruiting somatosensory cortex bilaterally
	Rosenthal Z.P.; Raut R.V.; Bowen R.M.; Snyder A.Z.; Culver J.P.; Raichle M.E.; Lee J.-M.
发表日期	2021
ISSN	00278424
卷号	118 期号:8
英文摘要	Slow waves (SWs) are globally propagating, low-frequency (0.5- to 4-Hz) oscillations that are prominent during sleep and anesthesia. SWs are essential to neural plasticity and memory. However, much remains unknown about the mechanisms coordinating SW propagation at the macroscale. To assess SWs in the context of macroscale networks, we recorded cortical activity in awake and ketamine/xylazine-anesthetized mice using widefield optical imaging with fluorescent calcium indicator GCaMP6f. We demonstrate that unilateral somatosensory stimulation evokes bilateral waves that travel across the cortex with state-dependent trajectories. Under anesthesia, we observe that rhythmic stimuli elicit globally resonant, front-to-back propagating SWs. Finally, photothrombotic lesions of S1 show that somatosensory-evoked global SWs depend on bilateral recruitment of homotopic primary somatosensory cortices. Specifically, unilateral lesions of S1 disrupt somatosensory-evoked global SW initiation from either hemisphere, while spontaneous SWs are largely unchanged. These results show that evoked SWs may be triggered by bilateral activation of specific, homotopically connected cortical networks. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Propagation; Slow wave; Somatosensory cortex
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180574
作者单位	Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110, United States; Graduate Program of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Physics, Washington University School of Medicine, St. Louis, MO 63110, United States
推荐引用方式 GB/T 7714	Rosenthal Z.P.,Raut R.V.,Bowen R.M.,et al. Peripheral sensory stimulation elicits global slow waves by recruiting somatosensory cortex bilaterally[J],2021,118(8).
APA	Rosenthal Z.P..,Raut R.V..,Bowen R.M..,Snyder A.Z..,Culver J.P..,...&Lee J.-M..(2021).Peripheral sensory stimulation elicits global slow waves by recruiting somatosensory cortex bilaterally.Proceedings of the National Academy of Sciences of the United States of America,118(8).
MLA	Rosenthal Z.P.,et al."Peripheral sensory stimulation elicits global slow waves by recruiting somatosensory cortex bilaterally".Proceedings of the National Academy of Sciences of the United States of America 118.8(2021).