气候变化领域集成服务门户(CCPortal): Cognitive aging is associated with redistribution of synaptic weights in the hippocampus

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DOI	10.1073/pnas.1921481118
	Cognitive aging is associated with redistribution of synaptic weights in the hippocampus
	Buss E.W.; Corbett N.J.; Roberts J.G.; Ybarra N.; Musial T.F.; Simkin D.; Molina-Campos E.; Oh K.-J.; Nielsen L.L.; Ayala G.D.; Mullen S.A.; Farooqi A.K.; D’Souza G.X.; Hill C.L.; Bean L.A.; Rogalsky A.E.; Russo M.L.; Curlik D.M.; Antion M.D.; Weiss C.; Chetkovich D.M.; Oh M.M.; Disterhoft J.F.; Nicholson D.A.
发表日期	2021
ISSN	00278424
卷号	118 期号:8
英文摘要	Behaviors that rely on the hippocampus are particularly susceptible to chronological aging, with many aged animals (including humans) maintaining cognition at a young adult-like level, but many others the same age showing marked impairments. It is unclear whether the ability to maintain cognition over time is attributable to brain maintenance, sufficient cognitive reserve, compensatory changes in network function, or some combination thereof. While network dysfunction within the hippocampal circuit of aged, learning-impaired animals is well-documented, its neurobiological substrates remain elusive. Here we show that the synaptic architecture of hippocampal regions CA1 and CA3 is maintained in a young adult-like state in aged rats that performed comparably to their young adult counterparts in both trace eyeblink conditioning and Morris water maze learning. In contrast, among learning-impaired, but equally aged rats, we found that a redistribution of synaptic weights amplifies the influence of autoassociational connections among CA3 pyramidal neurons, yet reduces the synaptic input onto these same neurons from the dentate gyrus. Notably, synapses within hippocampal region CA1 showed no group differences regardless of cognitive ability. Taking the data together, we find the imbalanced synaptic weights within hippocampal CA3 provide a substrate that can explain the abnormal firing characteristics of both CA3 and CA1 pyramidal neurons in aged, learning-impaired rats. Furthermore, our work provides some clarity with regard to how some animals cognitively age successfully, while others’ lifespans outlast their “mindspans.” © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Aging; Cognition; Hippocampus; Synapse
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180525
作者单位	Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, United States; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, United States
推荐引用方式 GB/T 7714	Buss E.W.,Corbett N.J.,Roberts J.G.,et al. Cognitive aging is associated with redistribution of synaptic weights in the hippocampus[J],2021,118(8).
APA	Buss E.W..,Corbett N.J..,Roberts J.G..,Ybarra N..,Musial T.F..,...&Nicholson D.A..(2021).Cognitive aging is associated with redistribution of synaptic weights in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America,118(8).
MLA	Buss E.W.,et al."Cognitive aging is associated with redistribution of synaptic weights in the hippocampus".Proceedings of the National Academy of Sciences of the United States of America 118.8(2021).