气候变化领域集成服务门户(CCPortal): Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks

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DOI	10.1073/pnas.2015285118
	Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks
	Bandela A.K.; Wagner N.; Sadihov H.; Morales-Reina S.; Chotera-Ouda A.; Basu K.; Cohen-Luria R.; de la Escosura A.; Ashkenasy G.
发表日期	2021
ISSN	00278424
卷号	118 期号:9
英文摘要	Many fundamental cellular and viral functions, including replication and translation, involve complex ensembles hosting synergistic activity between nucleic acids and proteins/peptides. There is ample evidence indicating that the chemical precursors of both nucleic acids and peptides could be efficiently formed in the prebiotic environment. Yet, studies on nonenzymatic replication, a central mechanism driving early chemical evolution, have focused largely on the activity of each class of these molecules separately. We show here that short nucleopeptide chimeras can replicate through autocatalytic and cross-catalytic processes, governed syn-ergistically by the hybridization of the nucleobase motifs and the assembly propensity of the peptide segments. Unequal assembly-dependent replication induces clear selectivity toward the formation of a certain species within small networks of complementary nucleopeptides. The selectivity pattern may be influenced and indeed maximized to the point of almost extinction of the weakest replicator when the system is studied far from equilibrium and manipulated through changes in the physical (flow) and chemical (template and inhibition) conditions. We postulate that similar processes may have led to the emergence of the first functional nucleic-acid-peptide assemblies prior to the origin of life. Furthermore, spontaneous formation of related replicating complexes could potentially mark the initiation point for information transfer and rapid progression in complexity within primitive environments, which would have facilitated the development of a variety of functions found in extant biological assemblies. © This open access article is distributed under Creative Commons Attribution-NonCommercialNoDerivatives License 4.0 (CC BY-NC-ND).
英文关键词	Chemical evolution; Molecular networks; Nucleic-acid-peptide conjugates; Self-replication
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180460
作者单位	Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel; Department of Organic Chemistry, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid, 28049, Spain; Institute for Advanced Research in Chemistry, Cantoblanco, Madrid, 28049, Spain; Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lodz, 90-363, Poland
推荐引用方式 GB/T 7714	Bandela A.K.,Wagner N.,Sadihov H.,et al. Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks[J],2021,118(9).
APA	Bandela A.K..,Wagner N..,Sadihov H..,Morales-Reina S..,Chotera-Ouda A..,...&Ashkenasy G..(2021).Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks.Proceedings of the National Academy of Sciences of the United States of America,118(9).
MLA	Bandela A.K.,et al."Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks".Proceedings of the National Academy of Sciences of the United States of America 118.9(2021).