气候变化领域集成服务门户(CCPortal): Emergent robustness of bacterial quorum sensing in fluid flow

CCPortal

DOI	10.1073/pnas.2022312118
	Emergent robustness of bacterial quorum sensing in fluid flow
	Dalwadi M.P.; Pearce P.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	Bacteria use intercellular signaling, or quorum sensing (QS), to share information and respond collectively to aspects of their surroundings. The autoinducers that carry this information are exposed to the external environment; consequently, they are affected by factors such as removal through fluid flow, a ubiquitous feature of bacterial habitats ranging from the gut and lungs to lakes and oceans. To understand how QS genetic architectures in cells promote appropriate population-level phenotypes throughout the bacterial life cycle requires knowledge of how these architectures determine the QS response in realistic spatiotemporally varying flow conditions. Here we develop and apply a general theory that identifies and quantifies the conditions required for QS activation in fluid flow by systematically linking cell- and population-level genetic and physical processes. We predict that when a subset of the population meets these conditions, cell-level positive feedback promotes a robust collective response by overcoming flow-induced autoinducer concentration gradients. By accounting for a dynamic flow in our theory, we predict that positive feedback in cells acts as a low-pass filter at the population level in oscillatory flow, allowing a population to respond only to changes in flow that occur over slow enough timescales. Our theory is readily extendable and provides a framework for assessing the functional roles of diverse QS network architectures in realistic flow conditions. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Bacterial signaling; Biofilms; Quorum sensing
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180394
作者单位	Mathematical Institute, University of Oxford, Oxford, OX2 6GG, United Kingdom; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, United States
推荐引用方式 GB/T 7714	Dalwadi M.P.,Pearce P.. Emergent robustness of bacterial quorum sensing in fluid flow[J],2021,118(10).
APA	Dalwadi M.P.,&Pearce P..(2021).Emergent robustness of bacterial quorum sensing in fluid flow.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Dalwadi M.P.,et al."Emergent robustness of bacterial quorum sensing in fluid flow".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).