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DOI	10.1073/pnas.2021048118
	Posttranslational regulation of multiple clock-related transcription factors triggers cold-inducible gene expression in Arabidopsis
	Kidokoro S.; Hayashi K.; Haraguchi H.; Ishikawa T.; Soma F.; Konoura I.; Toda S.; Mizoi J.; Suzuki T.; Shinozaki K.; Yamaguchi-Shinozaki K.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	Cold stress is an adverse environmental condition that affects plant growth, development, and crop productivity. Under cold stress conditions, the expression of numerous genes that function in the stress response and tolerance is induced in various plant species, and the dehydration-responsive element (DRE) binding protein 1/C-repeat binding factor (DREB1/CBF) transcription factors function as master switches for cold-inducible gene expression. Cold stress strongly induces these DREB1 genes. Therefore, it is important to elucidate the mechanisms of DREB1 expression in response to cold stress to clarify the perception and response of cold stress in plants. Previous studies indicated that the central oscillator components of the circadian clock, CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), are involved in cold-inducible DREB1 expression, but the underlying mechanisms are not clear. We revealed that the clock-related MYB proteins REVEILLE4/LHY-CCA1-Like1 (RVE4/LCL1) and RVE8/ LCL5 are quickly and reversibly transferred from the cytoplasm to the nucleus under cold stress conditions and function as direct transcriptional activators of DREB1 expression. We found that CCA1 and LHY suppressed the expression of DREB1s under unstressed conditions and were rapidly degraded specifically in response to cold stress, which suggests that they act as transcriptional repressors and indirectly regulate the cold-inducible expression of DREB1s. We concluded that posttranslational regulation of multiple clock-related transcription factors triggers cold-inducible gene expression. Our findings clarify the complex relationship between the plant circadian clock and the regulatory mechanisms of cold-inducible gene expression. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Arabidopsis; Circadian clock-related transcription factors; Cold stress responses; Cold-inducible DREB1/CBF expression; Posttranslational regulation
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180360
作者单位	Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan; College of Bioscience and Biotechnology, Chubu University, Aichi, 487-8501, Japan; Gene Discovery Research Group, RIKEN Center for Sustainable Resource Science, Tsukuba, 305-0074, Japan; Research Institute for Agricultural and Life Sciences, Tokyo University of Agriculture, Tokyo, 156-8502, Japan
推荐引用方式 GB/T 7714	Kidokoro S.,Hayashi K.,Haraguchi H.,et al. Posttranslational regulation of multiple clock-related transcription factors triggers cold-inducible gene expression in Arabidopsis[J],2021,118(10).
APA	Kidokoro S..,Hayashi K..,Haraguchi H..,Ishikawa T..,Soma F..,...&Yamaguchi-Shinozaki K..(2021).Posttranslational regulation of multiple clock-related transcription factors triggers cold-inducible gene expression in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Kidokoro S.,et al."Posttranslational regulation of multiple clock-related transcription factors triggers cold-inducible gene expression in Arabidopsis".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).