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DOI	10.1073/pnas.2022172118
	The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice
	Keshavarz M.; Tautz D.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	Mammalian genomes include many maternally and paternally imprinted genes. Most of these are also expressed in the brain, and several have been implicated in regulating specific behavioral traits. Here, we have used a knockout approach to study the function of Peg13, a gene that codes for a fast-evolving lncRNA (long noncoding RNA) and is part of a complex of imprinted genes on chromosome 15 in mice and chromosome 8 in humans. Mice lacking the 3′ half of the transcript look morphologically wild-type but show distinct behavioral differences. They lose interest in the opposite sex, instead displaying a preference for wild-type animals of the same sex. Further, they show a higher level of anxiety, lowered activity and curiosity, and a deficiency in pup retrieval behavior. Brain RNA expression analysis reveals that genes involved in the serotonergic system, formation of glutamatergic synapses, olfactory processing, and estrogen signaling—as well as more than half of the other known imprinted genes—show significant expression changes in Peg13-deficient mice. Intriguingly, these pathways are differentially affected in the sexes, resulting in male and female brains of Peg13-deficient mice differing more from each other than those of wild-type mice. We conclude that Peg13 is part of a developmental pathway that regulates the neurobiology of social and sexual interactions. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Behavior; Brain transcriptome; Imprinted genes; Partner preference
语种	英语
scopus关键词	estrogen; long untranslated RNA; transcriptome; adult; animal behavior; animal experiment; anxiety assessment; Article; chromosome 15; chromosome 8; controlled study; female; gene control; gene expression; gene function; gene knockout; genetic transcription; genome imprinting; glutamatergic synapse; human; human cell; intracellular signaling; male; mate choice; mouse; neurobiology; nonhuman; olfactory discrimination; Peg13 gene; priority journal; protein expression; protein function; reproductive behavior; RNA analysis; RNA gene; serotoninergic system; sex differentiation; social interaction; wild type mouse
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180336
作者单位	Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Plön, 24306, Germany
推荐引用方式 GB/T 7714	Keshavarz M.,Tautz D.. The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice[J],2021,118(10).
APA	Keshavarz M.,&Tautz D..(2021).The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Keshavarz M.,et al."The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).