气候变化领域集成服务门户(CCPortal): Loss of expression of both miR-15/16 loci in CML transition to blast crisis

CCPortal

DOI	10.1073/pnas.2101566118
	Loss of expression of both miR-15/16 loci in CML transition to blast crisis
	Lovat F.; Gasparini P.; Nigita G.; Larkin K.; Byrd J.C.; Minden M.D.; Andreeff M.; Carter B.Z.; Croce C.M.
发表日期	2021
ISSN	00278424
卷号	118 期号:11
英文摘要	Despite advances that have improved the treatment of chronic myeloid leukemia (CML) patients in chronic phase, the mechanisms of the transition from chronic phase CML to blast crisis (BC) are not fully understood. Considering the key role of miR-15/16 loci in the pathogenesis of myeloid and lymphocytic leukemia, here we aimed to correlate the expression of miR-15a/16 and miR-15b/16 to progression of CML from chronic phase to BC. We analyzed the expression of the two miR-15/16 clusters in 17 CML patients in chronic phase and 22 patients in BC and in 11 paired chronic phase and BC CML patients. BC CMLs show a significant reduction of the expression of miR-15a/-15b/16 compared to CMLs in chronic phase. Moreover, BC CMLs showed an overexpression of miR-15/16 direct targets such as Bmi-1, ROR1, and Bcl-2 compared to CMLs in chronic phase. This study highlights the loss of both miR-15/16 clusters as a potential oncogenic driver in the transition from chronic phase to BC in CML patients. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Blast crisis; Chronic myeloid leukemia; MiR-15/16 cluster
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180264
作者单位	Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, United States; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, United States; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia; Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, United States; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada; Section of Molecular Hematology and Therapy, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States
推荐引用方式 GB/T 7714	Lovat F.,Gasparini P.,Nigita G.,et al. Loss of expression of both miR-15/16 loci in CML transition to blast crisis[J],2021,118(11).
APA	Lovat F..,Gasparini P..,Nigita G..,Larkin K..,Byrd J.C..,...&Croce C.M..(2021).Loss of expression of both miR-15/16 loci in CML transition to blast crisis.Proceedings of the National Academy of Sciences of the United States of America,118(11).
MLA	Lovat F.,et al."Loss of expression of both miR-15/16 loci in CML transition to blast crisis".Proceedings of the National Academy of Sciences of the United States of America 118.11(2021).