气候变化领域集成服务门户(CCPortal): Early fMRI responses to somatosensory and optogenetic stimulation reflect neural information flow

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DOI	10.1073/pnas.2023265118
	Early fMRI responses to somatosensory and optogenetic stimulation reflect neural information flow
	Jung W.B.; Im G.H.; Jiang H.; Kim S.-G.
发表日期	2021
ISSN	00278424
卷号	118 期号:11
英文摘要	Blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has been widely used to localize brain functions. To further advance understanding of brain functions, it is critical to understand the direction of information flow, such as thalamocortical versus corticothalamic projections. For this work, we performed ultrahigh spatiotemporal resolution fMRI at 15.2 T of the mouse somatosensory network during forepaw somatosensory stimulation and optogenetic stimulation of the primary motor cortex (M1). Somatosensory stimulation induced the earliest BOLD response in the ventral posterolateral nucleus (VPL), followed by the primary somatosensory cortex (S1) and then M1 and posterior thalamic nucleus. Optogenetic stimulation of excitatory neurons in M1 induced the earliest BOLD response in M1, followed by S1 and then VPL. Within S1, the middle cortical layers responded to somatosensory stimulation earlier than the upper or lower layers, whereas the upper cortical layers responded earlier than the other two layers to optogenetic stimulation in M1. The order of early BOLD responses was consistent with the canonical understanding of somatosensory network connections and cannot be explained by regional variabilities in the hemodynamic response functions measured using hypercapnic stimulation. Our data demonstrate that early BOLD responses reflect the information flow in the mouse somatosensory network, suggesting that high-field fMRI can be used for systems-level network analyses. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Early BOLD response; FMRI; Hypercapnia; Optogenetics; Somatosensory network
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180258
作者单位	Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, 16419, South Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, 16419, South Korea; Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, 16419, South Korea
推荐引用方式 GB/T 7714	Jung W.B.,Im G.H.,Jiang H.,et al. Early fMRI responses to somatosensory and optogenetic stimulation reflect neural information flow[J],2021,118(11).
APA	Jung W.B.,Im G.H.,Jiang H.,&Kim S.-G..(2021).Early fMRI responses to somatosensory and optogenetic stimulation reflect neural information flow.Proceedings of the National Academy of Sciences of the United States of America,118(11).
MLA	Jung W.B.,et al."Early fMRI responses to somatosensory and optogenetic stimulation reflect neural information flow".Proceedings of the National Academy of Sciences of the United States of America 118.11(2021).