气候变化领域集成服务门户(CCPortal): Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer

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DOI	10.1073/pnas.1920879118
	Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer
	Park J.; Park B.; Kim T.Y.; Jung S.; Choi W.J.; Ahn J.; Yoon D.H.; Kim J.; Jeon S.; Lee D.; Yong U.; Jang J.; Kim W.J.; Kim H.K.; Jeong U.; Kim H.H.; Kim C.
发表日期	2021
ISSN	00278424
卷号	118 期号:11
英文摘要	Ultrasound and optical imagers are used widely in a variety of biological and medical applications. In particular, multimodal implementations combining light and sound have been actively investigated to improve imaging quality. However, the integration of optical sensors with opaque ultrasound transducers suffers from low signal-to-noise ratios, high complexity, and bulky form factors, significantly limiting its applications. Here, we demonstrate a quadruple fusion imaging system using a spherically focused transparent ultrasound transducer that enables seamless integration of ultrasound imaging with photoacoustic imaging, optical coherence tomography, and fluorescence imaging. As a first application, we comprehensively monitored multiparametric responses to chemical and suture injuries in rats' eyes in vivo, such as corneal neovascularization, structural changes, cataracts, and inflammation. As a second application, we successfully performed multimodal imaging of tumors in vivo, visualizing melanomas without using labels and visualizing 4T1 mammary carcinomas using PEGylated gold nanorods. We strongly believe that the seamlessly integrated multimodal system can be used not only in ophthalmology and oncology but also in other healthcare applications with broad impact and interest. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Multimodal imaging; Optical imaging; Transparent ultrasound transducer; Ultrasound imaging
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180246
作者单位	School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, 37673, South Korea; Medical Device Innovation Center, Pohang University of Science and Technology, Pohang, 37673, South Korea; Department of Creative IT Engineering, Pohang University of Science and Technology, Pohang, 37673, South Korea; Department of Materials Science and Engineering, Pohang University of Science and Technology, Pohang, 37673, South Korea; School of Electrical and Electronics Engineering, Chung-Ang University, Seoul, 06974, South Korea; Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 37673, South Korea; Department of Chemistry, Pohang University of Science and Technology, Pohang, 37673, South Korea; Department of Electrical Engineering, Pohang University of Science and Technology, Pohang, 37673, South Korea
推荐引用方式 GB/T 7714	Park J.,Park B.,Kim T.Y.,et al. Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer[J],2021,118(11).
APA	Park J..,Park B..,Kim T.Y..,Jung S..,Choi W.J..,...&Kim C..(2021).Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer.Proceedings of the National Academy of Sciences of the United States of America,118(11).
MLA	Park J.,et al."Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer".Proceedings of the National Academy of Sciences of the United States of America 118.11(2021).