气候变化领域集成服务门户(CCPortal): Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation

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DOI	10.1073/pnas.2022422118
	Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation
	Li H.; Zheng Y.; Han Y.L.; Cai S.; Guo M.
发表日期	2021
ISSN	00278424
卷号	118 期号:11
英文摘要	Basement membrane (BM) is a thin layer of extracellular matrix that surrounds most animal tissues, serving as a physical barrier while allowing nutrient exchange. Although they have important roles in tissue structural integrity, physical properties of BMs remain largely uncharacterized, which limits our understanding of their mechanical functions. Here, we perform pressure-controlled inflation and deflation to directly measure the nonlinear mechanics of BMs in situ. We show that the BMs behave as a permeable, hyperelastic material whose mechanical properties and permeability can be measured in amodel-independent manner. Furthermore, we find that BMs exhibit a remarkable nonlinear stiffening behavior, in contrast to the reconstituted Matrigel. This nonlinear stiffening behavior helps the BMs to avoid the snap-through instability (or structural softening) widely observed during the inflation of most elastomeric balloons and thus maintain sufficient confining stress to the enclosed tissues during their growth. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Basement membrane; Extracellular matrix; Nonlinear mechanics; Permeability; Strain stiffening
语种	英语
scopus关键词	kalinin; matrigel; Article; basement membrane; biomembrane; breast cancer; cell proliferation; diffusivity; elasticity; extracellular matrix; human; human cell; immunofluorescence; MDA-MB-231 cell line; membrane permeability; microinjection; nonlinear system; pressure measurement; priority journal; rigidity; transmission electron microscopy; tumor spheroid; tumor thickness
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180225
作者单位	School of Systems Science, Beijing Normal University, Beijing, 100875, China; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA 92093, United States
推荐引用方式 GB/T 7714	Li H.,Zheng Y.,Han Y.L.,et al. Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation[J],2021,118(11).
APA	Li H.,Zheng Y.,Han Y.L.,Cai S.,&Guo M..(2021).Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation.Proceedings of the National Academy of Sciences of the United States of America,118(11).
MLA	Li H.,et al."Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation".Proceedings of the National Academy of Sciences of the United States of America 118.11(2021).