气候变化领域集成服务门户(CCPortal): Disruption of neonatal Purkinje cell function underlies injury-related learning deficits

CCPortal

DOI	10.1073/pnas.2017876118
	Disruption of neonatal Purkinje cell function underlies injury-related learning deficits
	Sathyanesan A.; Kratimenos P.; Gallo V.
发表日期	2021
ISSN	00278424
卷号	118 期号:11
英文摘要	It is hypothesized that perinatal cerebellar injury leads to longterm functional deficits due to circuit dysmaturation. Using a novel integration of GCaMP6f fiber photometry with automated measurement of cerebellar behavior using the ErasmusLadder, we causally link cerebellar injury to altered Purkinje cell responses during maladaptive behavior. Chemogenetic inhibition of neonatal Purkinje cells is sufficient to phenocopy the effects of perinatal cerebellar injury. Our results uncover a direct link between perinatal cerebellar injury and activity-dependent maturation of cerebellar cortex. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Adaptive behavior; Cerebellum; Locomotor learning; Neonatal brain injury; Purkinje cell
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180224
作者单位	Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, DC 20010, United States; Department of Pediatrics, Division of Neonatology, Children's National Hospital, Washington, DC 20010, United States; The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, United States
推荐引用方式 GB/T 7714	Sathyanesan A.,Kratimenos P.,Gallo V.. Disruption of neonatal Purkinje cell function underlies injury-related learning deficits[J],2021,118(11).
APA	Sathyanesan A.,Kratimenos P.,&Gallo V..(2021).Disruption of neonatal Purkinje cell function underlies injury-related learning deficits.Proceedings of the National Academy of Sciences of the United States of America,118(11).
MLA	Sathyanesan A.,et al."Disruption of neonatal Purkinje cell function underlies injury-related learning deficits".Proceedings of the National Academy of Sciences of the United States of America 118.11(2021).