气候变化领域集成服务门户(CCPortal): Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood

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DOI	10.1073/pnas.2016580118
	Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood
	Brownlie D.; Scharenberg M.; Mold J.E.; Hard J.; Kekalainen E.; Buggert M.; Nguyen S.; Wilson J.N.; Al-Ameri M.; Ljunggren H.-G.; Marquardt N.; Michaelsson J.
发表日期	2021
ISSN	00278424
卷号	118 期号:11
英文摘要	Human adaptive-like "memory" CD56dimCD16+natural killer (NK) cells in peripheral blood from cytomegalovirus-seropositive individuals have been extensively investigated in recent years and are currently explored as a treatment strategy for hematological cancers. However, treatment of solid tumors remains limited due to insufficient NK cell tumor infiltration, and it is unknown whether large expansions of adaptive-like NK cells that are equipped for tissue residency and tumor homing exist in peripheral tissues. Here, we show that human lung and blood contains adaptivelike CD56brightCD16-NK cells with hallmarks of tissue residency, including expression of CD49a. Expansions of adaptive-like lung tissue-resident NK (trNK) cells were found to be present independently of adaptive-like CD56dimCD16+NK cells and to be hyperresponsive toward target cells. Together, our data demonstrate that phenotypically, functionally, and developmentally distinct subsets of adaptive-like NK cells exist in human lung and blood. Given their tissue-related character and hyperresponsiveness, human lung adaptive-like trNK cells might represent a suitable alternative for therapies targeting solid tumors. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Adaptive; Lung; Memory; NK cells; Tissue-resident
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180219
作者单位	Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, 14152, Sweden; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, 171 77, Sweden; Translational Immunology Research Program, University of Helsinki, Helsinki, 00014, Finland; Department of Bacteriology and Immunology, University of Helsinki, Helsinki, 00014, Finland; Helsinki University Central Hospital Laboratory, Division of Clinical Microbiology, Helsinki University Hospital, Helsinki, 00290, Finland; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Thoracic Surgery, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, 171 76, Sweden
推荐引用方式 GB/T 7714	Brownlie D.,Scharenberg M.,Mold J.E.,et al. Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood[J],2021,118(11).
APA	Brownlie D..,Scharenberg M..,Mold J.E..,Hard J..,Kekalainen E..,...&Michaelsson J..(2021).Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood.Proceedings of the National Academy of Sciences of the United States of America,118(11).
MLA	Brownlie D.,et al."Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood".Proceedings of the National Academy of Sciences of the United States of America 118.11(2021).