气候变化领域集成服务门户(CCPortal): A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism

CCPortal

DOI	10.1073/PNAS.2013239118
	A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism
	Rella L.; Povoa E.E.F.; Mars J.; Ebbing A.L.P.; Schoppink L.; Betist M.C.; Korswagen H.C.
发表日期	2021
ISSN	00278424
卷号	118 期号:12
英文摘要	Members of the Wnt family of secreted glycoproteins regulate cell migration through distinct canonical and noncanonical signaling pathways. Studies of vertebrate development and disease have shown that these pathways can have opposing effects on cell migration, but the mechanism of this functional interplay is not known. In the nematode Caenorhabditis elegans, a switch from noncanonical to canonical Wnt signaling terminates the longrange migration of the QR neuroblast descendants, providing a tractable system to study this mechanism in vivo. Here, we show that noncanonical Wnt signaling acts through PIX-1/RhoGEF, while canonical signaling directly activates the Slt-Robo pathway component EVA-1/EVA1C and the Rho GTPase-activating protein RGA-9b/ARHGAP, which are required for migration inhibition. Our results support a model in which cross-talk between noncanonical and canonical Wnt signaling occurs through antagonistic regulation of the Rho GTPases that drive cell migration. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	C. elegans; Cell migration; Pathway interactions; Slt-Robo; Wnt
语种	英语
scopus关键词	beta catenin; cell protein; CWN 1 protein; EVA 1 protein; EVA1C protein; frizzled protein; MOM 5 protein; p21 activated kinase interacting exchange factor 1 protein; Rho GTPase activating protein 9b; Rho guanine nucleotide binding protein; Rho guanine nucleotide exchange factor; roundabout receptor; Slt protein; unclassified drug; Wnt protein; adult; allele; Article; Caenorhabditis elegans; cell lineage; controlled study; eva 1 gene; gene; gene function; gene interaction; genetic association; genetic conservation; genetic transcription; migration inhibition; molecular interaction; neuroblast; nonhuman; priority journal; regulatory mechanism; rga 9 gene; upregulation; Wnt signaling
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180207
作者单位	Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University Medical Center Utrecht, Utrecht, 3584 CT, Netherlands; Institute of Biodynamics and Biocomplexity, Developmental Biology, Department of Biology, Utrecht University, Utrecht, 3584 CH, Netherlands
推荐引用方式 GB/T 7714	Rella L.,Povoa E.E.F.,Mars J.,et al. A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism[J],2021,118(12).
APA	Rella L..,Povoa E.E.F..,Mars J..,Ebbing A.L.P..,Schoppink L..,...&Korswagen H.C..(2021).A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism.Proceedings of the National Academy of Sciences of the United States of America,118(12).
MLA	Rella L.,et al."A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021).