气候变化领域集成服务门户(CCPortal): Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury

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DOI	10.1073/PNAS.2021758118
	Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury
	Tanaka S.; Abe C.; Abbott S.B.G.; Zheng S.; Yamaoka Y.; Lipsey J.E.; Skrypnyk N.I.; Yao J.; Inoue T.; Nash W.T.; Stornetta D.S.; Rosin D.L.; Stornetta R.L.; Guyenet P.G.; Okusa M.D.
发表日期	2021
ISSN	00278424
卷号	118 期号:12
英文摘要	Acute kidney injury is highly prevalent and associated with high morbidity and mortality, and there are no approved drugs for its prevention and treatment. Vagus nerve stimulation (VNS) alleviates inflammatory diseases including kidney disease; however, neural circuits involved in VNS-induced tissue protection remain poorly understood. The vagus nerve, a heterogeneous group of neural fibers, innervates numerous organs. VNS broadly stimulates these fibers without specificity. We used optogenetics to selectively stimulate vagus efferent or afferent fibers. Anterograde efferent fiber stimulation or anterograde (centripetal) sensory afferent fiber stimulation both conferred kidney protection from ischemia-reperfusion injury. We identified the C1 neurons-sympathetic nervous system-splenic nerve-spleen-kidney axis as the downstream pathway of vagus afferent fiber stimulation. Our study provides a map of the neural circuits important for kidney protection induced by VNS, which is critical for the safe and effective clinical application of VNS for protection from acute kidney injury. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Acute kidney injury; Neuroimmune interactions; Sympathetic nervous system; Vagus nerve stimulation
语种	英语
scopus关键词	adrenergic system; animal experiment; animal tissue; Article; clinical effectiveness; controlled study; efferent nerve; kidney injury; male; mouse; nerve cell; nerve potential; neuroimmunology; nonhuman; optogenetics; priority journal; renal ischemia reperfusion injury; renal protection; safety; sensory nerve; spleen; vagus nerve stimulation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180205
作者单位	Division of Nephrology, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, United States; Department of Physiology, Gifu University, Graduate School of Medicine, Gifu, 501-1194, Japan; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, United States; Division of Chronic Kidney Disease Pathophysiology, University of Tokyo, Graduate School of Medicine, Tokyo, 113-0033, Japan
推荐引用方式 GB/T 7714	Tanaka S.,Abe C.,Abbott S.B.G.,et al. Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury[J],2021,118(12).
APA	Tanaka S..,Abe C..,Abbott S.B.G..,Zheng S..,Yamaoka Y..,...&Okusa M.D..(2021).Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury.Proceedings of the National Academy of Sciences of the United States of America,118(12).
MLA	Tanaka S.,et al."Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021).