气候变化领域集成服务门户(CCPortal): Evidence supporting a time-limited hippocampal role in retrieving autobiographical memories

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DOI	10.1073/pnas.2023069118
	Evidence supporting a time-limited hippocampal role in retrieving autobiographical memories
	Gilmore A.W.; Quach A.; Kalinowski S.E.; González-Araya E.I.; Gotts S.J.; Schacter D.L.; Martin A.
发表日期	2021
ISSN	00278424
卷号	118 期号:12
英文摘要	The necessity of the human hippocampus for remote autobiographical recall remains fiercely debated. The standard model of consolidation predicts a time-limited role for the hippocampus, but the competing multiple trace/trace transformation theories posit indefinite involvement. Lesion evidence remains inconclusive, and the inferences one can draw from functional MRI (fMRI) have been limited by reliance on covert (silent) recall, which obscures dynamic, moment-to-moment content of retrieved memories. Here, we capitalized on advances in fMRI denoising to employ overtly spoken recall. Forty participants retrieved recent and remote memories, describing each for approximately 2 min. Details associated with each memory were identified and modeled in the fMRI time-series data using a variant of the Autobiographical Interview procedure, and activity associated with the recall of recent and remote memories was then compared. Posterior hippocampal regions exhibited temporally graded activity patterns (recent events > remote events), as did several regions of frontal and parietal cortex. Consistent with predictions of the standard model, recall-related hippocampal activity differed from a non-autobiographical control task only for recent, and not remote, events. Task-based connectivity between posterior hippocampal regions and others associated with mental scene construction also exhibited a temporal gradient, with greater connectivity accompanying the recall of recent events. These findings support predictions of the standard model of consolidation and demonstrate the potential benefits of overt recall in neuroimaging experiments. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Autobiographical memory \| fMRI \| hippocampus \| parietal cortex \| spoken recall
语种	英语
scopus关键词	adult; article; autobiographical memory; clinical article; controlled study; female; frontoparietal cortex; functional magnetic resonance imaging; hippocampus; human; human experiment; interview; long term memory; male; memory; neuroimaging; prediction; time series analysis
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180166
作者单位	Section on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, MD 20892, United States; Department of Psychology, Harvard University, Cambridge, MA 02138, United States
推荐引用方式 GB/T 7714	Gilmore A.W.,Quach A.,Kalinowski S.E.,et al. Evidence supporting a time-limited hippocampal role in retrieving autobiographical memories[J],2021,118(12).
APA	Gilmore A.W..,Quach A..,Kalinowski S.E..,González-Araya E.I..,Gotts S.J..,...&Martin A..(2021).Evidence supporting a time-limited hippocampal role in retrieving autobiographical memories.Proceedings of the National Academy of Sciences of the United States of America,118(12).
MLA	Gilmore A.W.,et al."Evidence supporting a time-limited hippocampal role in retrieving autobiographical memories".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021).