气候变化领域集成服务门户(CCPortal): Meis homeobox genes control progenitor competence in the retina

CCPortal

DOI	10.1073/pnas.2013136118
	Meis homeobox genes control progenitor competence in the retina
	Dupacova N.; Antosova B.; Paces J.; Kozmik Z.
发表日期	2021
ISSN	00278424
卷号	118 期号:12
英文摘要	The vertebrate eye is derived from the neuroepithelium, surface ectoderm, and extracellular mesenchyme. The neuroepithelium forms an optic cup in which the spatial separation of three domains is established, namely, the region of multipotent retinal progenitor cells (RPCs), the ciliary margin zone (CMZ)—which possesses both a neurogenic and nonneurogenic potential—and the optic disk (OD), the interface between the optic stalk and the neuroretina. Here, we show by genetic ablation in the developing optic cup that Meis1 and Meis2 homeobox genes function redundantly to maintain the retinal progenitor pool while they simultaneously suppress the expression of genes characteristic of CMZ and OD fates. Furthermore, we demonstrate that Meis transcription factors bind regulatory regions of RPC-, CMZ-, and OD-specific genes, thus providing a mechanistic insight into the Meis-dependent gene regulatory network. Our work uncovers the essential role of Meis1 and Meis2 as regulators of cell fate competence, which organize spatial territories in the vertebrate eye. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Retina \| Meis \| development
语种	英语
scopus关键词	beta catenin; homeodomain protein; animal cell; animal experiment; animal tissue; Article; binding affinity; cell cycle; cell death; cell fate; chromatin immunoprecipitation; ciliary process; controlled study; embryo; gene control; gene deletion; gene regulatory network; gene repression; homeobox; Meis1 gene; Meis2 gene; mouse; neuroepithelium; nonhuman; optic disk cup; priority journal; retina; retina development; RNA sequencing; stem cell; Wnt signaling
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180155
作者单位	Laboratory of Transcriptional Regulation, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague 4, 142 20, Czech Republic; Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague 4, 142 20, Czech Republic
推荐引用方式 GB/T 7714	Dupacova N.,Antosova B.,Paces J.,et al. Meis homeobox genes control progenitor competence in the retina[J],2021,118(12).
APA	Dupacova N.,Antosova B.,Paces J.,&Kozmik Z..(2021).Meis homeobox genes control progenitor competence in the retina.Proceedings of the National Academy of Sciences of the United States of America,118(12).
MLA	Dupacova N.,et al."Meis homeobox genes control progenitor competence in the retina".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021).