气候变化领域集成服务门户(CCPortal): Experimental competition induces immediate and lasting effects on the neurogenome in free-living female birds

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DOI	10.1073/pnas.2016154118
	Experimental competition induces immediate and lasting effects on the neurogenome in free-living female birds
	Bentz A.B.; George E.M.; Wolf S.E.; Rusch D.B.; Podicheti R.; Buechlein A.; Nephew K.P.; Rosvall K.A.
发表日期	2021
ISSN	00278424
卷号	118 期号:13
英文摘要	Periods of social instability can elicit adaptive phenotypic plasticity to promote success in future competition. However, the underlying molecular mechanisms have primarily been studied in captive and laboratory-reared animals, leaving uncertainty as to how natural competition among free-living animals affects gene activity. Here, we experimentally generated social competition among wild, cavity-nesting female birds (tree swallows, Tachycineta bicolor). After territorial settlement, we reduced the availability of key breeding resources (i.e., nest boxes), generating heightened competition; within 24 h we reversed the manipulation, causing aggressive interactions to subside. We sampled females during the peak of competition and 48 h after it ended, along with date-matched controls. We measured transcriptomic and epigenomic responses to competition in two socially relevant brain regions (hypothalamus and ventromedial telencephalon). Gene network analyses suggest that processes related to energy mobilization and aggression (e.g., dopamine synthesis) were up-regulated during competition, the latter of which persisted 2 d after competition had ended. Cellular maintenance processes were also down-regulated after competition. Competition additionally altered methylation patterns, particularly in pathways related to hormonal signaling, suggesting those genes were transcriptionally poised to respond to future competition. Thus, experimental competition among free-living animals shifts gene expression in ways that may facilitate the demands of competition at the expense of self-maintenance. Further, some of these effects persisted after competition ended, demonstrating the potential for epigenetic biological embedding of the social environment in ways that may prime individuals for success in future social instability. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Dopamine; Epigenetic; Gene network; MethylCap-seq; RNA-seq
语种	英语
scopus关键词	adult; aggressiveness; animal experiment; animal tissue; Article; artificial neural network; breeding; cell function; controlled study; dopamine metabolism; down regulation; embedding; energy yield; epigenetic modification; epigenetics; female; free living animal; gene activity; gene expression; genetic manipulation; genetic transcription; hormone action; hypothalamus; interspecific competition; nesting; neurogenomics; nonhuman; priority journal; RNA sequencing; social behavior; social environment; telencephalon; territoriality; transcriptomics; tree swallow; upregulation; young adult; zona incerta
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180083
作者单位	Department of Biology, Indiana University, Bloomington, IN 47405, United States; Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN 47405, United States; Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405, United States; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN 47405, United States
推荐引用方式 GB/T 7714	Bentz A.B.,George E.M.,Wolf S.E.,et al. Experimental competition induces immediate and lasting effects on the neurogenome in free-living female birds[J],2021,118(13).
APA	Bentz A.B..,George E.M..,Wolf S.E..,Rusch D.B..,Podicheti R..,...&Rosvall K.A..(2021).Experimental competition induces immediate and lasting effects on the neurogenome in free-living female birds.Proceedings of the National Academy of Sciences of the United States of America,118(13).
MLA	Bentz A.B.,et al."Experimental competition induces immediate and lasting effects on the neurogenome in free-living female birds".Proceedings of the National Academy of Sciences of the United States of America 118.13(2021).