气候变化领域集成服务门户(CCPortal): A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior

CCPortal

DOI	10.1073/pnas.2014784118
	A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior
	Graf J.; Zhang C.; Marguet S.L.; Herrmann T.; Flossmann T.; Hinsch R.; Rahmati V.; Guenther M.; Frahm C.; Urbach A.; Neves R.M.; Witte O.W.; Kiebel S.J.; Isbrandt D.; Hübner C.A.; Holthoff K.; Kirmse K.
发表日期	2021
ISSN	00278424
卷号	118 期号:14
英文摘要	NKCC1 is the primary transporter mediating chloride uptake in immature principal neurons, but its role in the development of in vivo network dynamics and cognitive abilities remains unknown. Here, we address the function of NKCC1 in developing mice using electrophysiological, optical, and behavioral approaches. We report that NKCC1 deletion from telencephalic glutamatergic neurons decreases in vitro excitatory actions of γ-aminobutyric acid (GABA) and impairs neuronal synchrony in neonatal hippocampal brain slices. In vivo, it has a minor impact on correlated spontaneous activity in the hippocampus and does not affect network activity in the intact visual cortex. Moreover, long-term effects of the developmental NKCC1 deletion on synaptic maturation, network dynamics, and behavioral performance are subtle. Our data reveal a neural network function of NKCC1 in hippocampal glutamatergic neurons in vivo, but challenge the hypothesis that NKCC1 is essential for major aspects of hippocampal development. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Development; GABA; Hippocampus; In vivo; NKCC1
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180013
作者单位	Hans-Berger Department of Neurology, Jena University Hospital, Jena, 07747, Germany; Institute for Molecular and Behavioral Neuroscience, University of Cologne, Cologne, 50937, Germany; Experimental Neurophysiology, German Center for Neurodegenerative Diseases, Bonn, 53127, Germany; Institute of Human Genetics, Jena University Hospital, Jena, 07747, Germany; Department of Psychology, Technical University Dresden, Dresden, 01187, Germany; Department of Neurophysiology, Institute of Physiology, University of Würzburg, Würzburg, 97070, Germany
推荐引用方式 GB/T 7714	Graf J.,Zhang C.,Marguet S.L.,et al. A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior[J],2021,118(14).
APA	Graf J..,Zhang C..,Marguet S.L..,Herrmann T..,Flossmann T..,...&Kirmse K..(2021).A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior.Proceedings of the National Academy of Sciences of the United States of America,118(14).
MLA	Graf J.,et al."A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior".Proceedings of the National Academy of Sciences of the United States of America 118.14(2021).