气候变化领域集成服务门户(CCPortal): Subthalamic low-frequency oscillations predict vulnerability to cocaine addiction

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DOI	10.1073/pnas.2024121118
	Subthalamic low-frequency oscillations predict vulnerability to cocaine addiction
	Degoulet M.; Tiran-Cappello A.; Combrisson E.; Baunez C.; Pelloux Y.
发表日期	2021
ISSN	00278424
卷号	118 期号:14
英文摘要	Identifying vulnerable individuals before they transition to a compulsive pattern of drug seeking and taking is a key challenge in addiction to develop efficient prevention strategies. Oscillatory activity within the subthalamic nucleus (STN) has been associated with compulsive-related disorders. To study compulsive cocaineseeking behavior, a core component of drug addiction, we have used a rat model in which cocaine seeking despite a foot-shock contingency only emerges in some vulnerable individuals having escalated their cocaine intake. We show that abnormal oscillatory activity within the alpha/theta and low-beta bands during the escalation of cocaine intake phase predicts the subsequent emergence of compulsive-like seeking behavior. In fact, mimicking STN pathological activity in noncompulsive rats during cocaine escalation turns them into compulsive ones. We also find that 30 Hz, but not 130 Hz, STN deep brain stimulation (DBS) reduces pathological cocaine seeking in compulsive individuals. Our results identify an early electrical signature of future compulsive-like cocaine-seeking behavior and further advocates the use of frequency-dependent STN DBS for the treatment of addiction. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Addiction; Compulsive seeking; Deep brain stimulation; Electrical biomarker; Subthalamic nucleus
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179996
作者单位	Institut de Neurosciences de la Timone, UMR7289 CNRS, Marseille, 13005, France; Institut de Neurosciences de la Timone, UMR7289 Aix-Marseille Université, Marseille, 13005, France
推荐引用方式 GB/T 7714	Degoulet M.,Tiran-Cappello A.,Combrisson E.,et al. Subthalamic low-frequency oscillations predict vulnerability to cocaine addiction[J],2021,118(14).
APA	Degoulet M.,Tiran-Cappello A.,Combrisson E.,Baunez C.,&Pelloux Y..(2021).Subthalamic low-frequency oscillations predict vulnerability to cocaine addiction.Proceedings of the National Academy of Sciences of the United States of America,118(14).
MLA	Degoulet M.,et al."Subthalamic low-frequency oscillations predict vulnerability to cocaine addiction".Proceedings of the National Academy of Sciences of the United States of America 118.14(2021).