气候变化领域集成服务门户(CCPortal): ICAM-1 orchestrates the abscopal effect of tumor radiotherapy

CCPortal

DOI	10.1073/pnas.2010333118
	ICAM-1 orchestrates the abscopal effect of tumor radiotherapy
	Zhao Y.; Zhang T.; Wang Y.; Lu D.; Du J.; Feng X.; Zhou H.; Liu N.; Zhu H.; Qin S.; Liu C.; Gao X.; Yang Z.; Liu Z.
发表日期	2021
ISSN	00278424
卷号	118 期号:14
英文摘要	Compelling evidence indicates that radiotherapy (RT) has a systemic inhibitory effect on nonirradiated lesions (abscopal effect) in addition to the ablation of irradiated tumors. However, this effect occurs only in rare circumstances in clinical practice, and mechanisms underlying the abscopal effect of RT are neither fully understood nor therapeutically utilized. Here we identified that intercellular adhesion molecule-1 (ICAM-1), an inducible glycoprotein of the immunoglobulin superfamily, is up-regulated in nonirradiated tumors responsive to RT. ICAM-1 expression in preclinical animal models can be noninvasively detected by optical imaging and positron emission tomography (PET) using near-infrared fluorescence dye- and 64Cu-labeled imaging probes that we synthesized, respectively. Importantly, the expression levels of ICAM-1 determined by quantitative PET imaging showed a strong negative linear correlation with the growth of nonirradiated tumors. Moreover, genetic or pharmacologic up-regulation of ICAM-1 expression by either an intratumoral injection of engineered recombinant adenovirus or systemic administration of a Toll-like receptor 7 agonist-capsulated nanodrug could induce markedly increased abscopal responses to local RT in animal models. Mechanistic investigation revealed that ICAM-1 expression can enhance both the activation and tumor infiltration of CD8+ T cells to improve the responses of the nonirradiated tumors to RT. Together, our findings suggest that noninvasive PET imaging of ICAM-1 expression could be a powerful means to predict the responses of nonirradiated tumors to RT, which could facilitate the exploration of new combination RT strategies for effective ablation of primary and disseminated lesions. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Abscopal effect; ICAM-1; Positron emission tomography; Radiotherapy; Toll-like receptor
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179995
作者单位	Medical Isotopes Research Center, Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Health Science Center, Beijing, 100191, China; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, 100142, China; Department of Radiation Oncology, Peking University, First Hospital, Beijing, 100034, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China
推荐引用方式 GB/T 7714	Zhao Y.,Zhang T.,Wang Y.,et al. ICAM-1 orchestrates the abscopal effect of tumor radiotherapy[J],2021,118(14).
APA	Zhao Y..,Zhang T..,Wang Y..,Lu D..,Du J..,...&Liu Z..(2021).ICAM-1 orchestrates the abscopal effect of tumor radiotherapy.Proceedings of the National Academy of Sciences of the United States of America,118(14).
MLA	Zhao Y.,et al."ICAM-1 orchestrates the abscopal effect of tumor radiotherapy".Proceedings of the National Academy of Sciences of the United States of America 118.14(2021).