气候变化领域集成服务门户(CCPortal): Bacterial-induced pH shifts link individual cell physiology to macroscale collective behavior

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DOI	10.1073/pnas.2014346118
	Bacterial-induced pH shifts link individual cell physiology to macroscale collective behavior
	Dharanishanthi V.; Orgad A.; Rotem N.; Hagai E.; Kerstnus-Banchik J.; Ben-Ari J.; Harig T.; Ravella S.R.; Schulz S.; Helman Y.
发表日期	2021
ISSN	00278424
卷号	118 期号:14
英文摘要	Bacteria have evolved a diverse array of signaling pathways that enable them to quickly respond to environmental changes. Understanding how these pathways reflect environmental conditions and produce an orchestrated response is an ongoing challenge. Herein, we present a role for collective modifications of environmental pH carried out by microbial colonies living on a surface. We show that by collectively adjusting the local pH value, Paenibacillus spp., specifically, regulate their swarming motility. Moreover, we show that such pH-dependent regulation can converge with the carbon repression pathway to down-regulate flagellin expression and inhibit swarming in the presence of glucose. Interestingly, our results demonstrate that the observed glucose-dependent swarming repression is not mediated by the glucose molecule per se, as commonly thought to occur in carbon repression pathways, but rather is governed by a decrease in pH due to glucose metabolism. In fact, modification of the environmental pH by neighboring bacterial species could override this glucose-dependent repression and induce swarming of Paenibacillus spp. away from a glucose-rich area. Our results suggest that bacteria can use local pH modulations to reflect nutrient availability and link individual bacterial physiology to macroscale collective behavior. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Carbon catabolite repression; Paenibacillus spp.; PH modulation; Swarming
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179956
作者单位	Department of Plant Pathology and Microbiology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel; The Interdepartmental Unit, Mass Spectrometry and Chromatography Laboratory, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel; Institute of Organic Chemistry, Technische Universität, Braunschweig, 38106, Germany
推荐引用方式 GB/T 7714	Dharanishanthi V.,Orgad A.,Rotem N.,et al. Bacterial-induced pH shifts link individual cell physiology to macroscale collective behavior[J],2021,118(14).
APA	Dharanishanthi V..,Orgad A..,Rotem N..,Hagai E..,Kerstnus-Banchik J..,...&Helman Y..(2021).Bacterial-induced pH shifts link individual cell physiology to macroscale collective behavior.Proceedings of the National Academy of Sciences of the United States of America,118(14).
MLA	Dharanishanthi V.,et al."Bacterial-induced pH shifts link individual cell physiology to macroscale collective behavior".Proceedings of the National Academy of Sciences of the United States of America 118.14(2021).