气候变化领域集成服务门户(CCPortal): Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination

CCPortal

DOI	10.1073/pnas.2022928118
	Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination
	Lopez Angel C.J.; Pham E.A.; Du H.; Vallania F.; Fram B.J.; Perez K.; Nguyen T.; Rosenberg-Hasson Y.; Ahmed A.; Dekker C.L.; Grant P.M.; Khatri P.; Maecker H.T.; Glenn J.S.; Davis M.M.; Furman D.
发表日期	2021
ISSN	00278424
卷号	118 期号:14
英文摘要	Chronic inflammation is thought to be a major cause of morbidity and mortality in aging, but whether similar mechanisms underlie dysfunction in infection-associated chronic inflammation is unclear. Here, we profiled the immune proteome, and cellular composition and signaling states in a cohort of aging individuals versus a set of HIV patients on long-term antiretroviral therapy therapy or hepatitis C virus (HCV) patients before and after sofosbuvir treatment. We found shared alterations in aging-associated and infection-associated chronic inflammation including T cell memory inflation, up-regulation of intracellular signaling pathways of inflammation, and diminished sensitivity to cytokines in lymphocytes and myeloid cells. In the HIV cohort, these dysregulations were evident despite viral suppression for over 10 y. Viral clearance in the HCV cohort partially restored cellular sensitivity to interferon-α, but many immune system alterations persisted for at least 1 y posttreatment. Our findings indicate that in the HIV and HCV cohorts, a broad remodeling and degradation of the immune system can persist for a year or more, even after the removal or drastic reduction of the pathogen load and that this shares some features of chronic inflammation in aging. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Aging; Chronic inflammation; HCV; HIV; Systems immunology
语种	英语
scopus关键词	alpha interferon; proteome; sofosbuvir; aging; antiretroviral therapy; Article; bone marrow cell; cell composition; chronic inflammation; clinical feature; cohort analysis; controlled study; cytokine response; degradation; hepatitis C; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; immune dysregulation; immunology; lymphocyte; memory T lymphocyte; nonhuman; pathogen load; priority journal; sensitivity analysis; signal transduction; upregulation; viral clearance
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179953
作者单位	Department of Microbiology and Immunology, Stanford University, School of Medicine, Stanford, CA 94304, United States; Institute for Immunity Transplantation and Infection, Stanford University, School of Medicine, Stanford, CA 94304, United States; Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94304, United States; Buck Institute for Research on Aging, Novato, CA 94947, United States; Davis School of Gerontology, University of Southern California, Los Angeles, CA 90007, United States; Stanford Center for Biomedical Informatics Research, Department of Medicine, Stanford University, School of Medicine, Stanford, CA 94304, United States; Human Immune Monitoring Center, Stanford University, School of Medicine, Stanford, CA 94304, United States; Division of Infectious Diseases, Department of Pediatrics, Stanford University, School of Medicine, Stanford, CA 94304, United States; Division of Infectious Diseases, Department of Med...
推荐引用方式 GB/T 7714	Lopez Angel C.J.,Pham E.A.,Du H.,et al. Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination[J],2021,118(14).
APA	Lopez Angel C.J..,Pham E.A..,Du H..,Vallania F..,Fram B.J..,...&Furman D..(2021).Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination.Proceedings of the National Academy of Sciences of the United States of America,118(14).
MLA	Lopez Angel C.J.,et al."Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination".Proceedings of the National Academy of Sciences of the United States of America 118.14(2021).