气候变化领域集成服务门户(CCPortal): Morphological integration of the human brain across adolescence and adulthood

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DOI	10.1073/pnas.2023860118
	Morphological integration of the human brain across adolescence and adulthood
	Nadig A.; Seidlitz J.; McDermott C.L.; Liu S.; Bethlehem R.; Moore T.M.; Mallard T.T.; Clasen L.S.; Blumenthal J.D.; Lalonde F.; Gur R.C.; Gur R.E.; Bullmore E.T.; Satterthwaite T.D.; Raznahan A.
发表日期	2021
ISSN	00278424
卷号	118 期号:14
英文摘要	Brain structural covariance norms capture the coordination of neurodevelopmental programs between different brain regions. We develop and apply anatomical imbalance mapping (AIM), a method to measure and model individual deviations from these norms, to provide a lifespan map of morphological integration in the human cortex. In cross-sectional and longitudinal data, analysis of whole-brain average anatomical imbalance reveals a reproducible tightening of structural covariance by age 25 y, which loosens after the seventh decade of life. Anatomical imbalance change in development and in aging is greatest in the association cortex and least in the sensorimotor cortex. Finally, we show that interindividual variation in whole-brain average anatomical imbalance is positively correlated with a marker of human prenatal stress (birthweight disparity between monozygotic twins) and negatively correlated with general cognitive ability. This work provides methods and empirical insights to advance our understanding of coordinated anatomical organization of the human brain and its interindividual variation. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cerebral cortex; Development; Lifespan
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179951
作者单位	Harvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115, United States; Section on Developmental Neurogenomics, National Institute of Mental Health, Bethesda, MD 20892, United States; Department of Child and Adolescent Psychiatry and Behavioral Science, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States; Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, United States; Department of Psychiatry, University of Cambridge, Cambridge, CB2 1TN, United Kingdom; Department of Psychology, University of Texas at Austin, Austin, TX 78712, United States; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, CB2 1TN, United Kingdom
推荐引用方式 GB/T 7714	Nadig A.,Seidlitz J.,McDermott C.L.,et al. Morphological integration of the human brain across adolescence and adulthood[J],2021,118(14).
APA	Nadig A..,Seidlitz J..,McDermott C.L..,Liu S..,Bethlehem R..,...&Raznahan A..(2021).Morphological integration of the human brain across adolescence and adulthood.Proceedings of the National Academy of Sciences of the United States of America,118(14).
MLA	Nadig A.,et al."Morphological integration of the human brain across adolescence and adulthood".Proceedings of the National Academy of Sciences of the United States of America 118.14(2021).