气候变化领域集成服务门户(CCPortal): Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal

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DOI	10.1073/pnas.2103090118
	Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal
	Sutton A.K.; Goforth P.B.; Gonzalez I.E.; Dell'Orco J.; Pei H.; Myers M.G.; Jr.; Olson D.P.
发表日期	2021
ISSN	00278424
卷号	118 期号:15
英文摘要	The ventromedial hypothalamus (VMH) is a critical neural node that senses blood glucose and promotes glucose utilization or mobilization during hypoglycemia. The VMH neurons that control these distinct physiologic processes are largely unknown. Here, we show that melanocortin 3 receptor (Mc3R)-expressing VMH neurons (VMHMC3R) sense glucose changes both directly and indirectly via altered excitatory input. We identify presynaptic nodes that potentially regulate VMHMC3R neuronal activity, including inputs from proopiomelanocortin (POMC)-producing neurons in the arcuate nucleus. We find that VMHMC3R neuron activation blunts, and their silencing enhances glucose excursion following a glucose load. Overall, these findings demonstrate that VMHMC3R neurons are a glucose-responsive hypothalamic subpopulation that promotes glucose disposal upon activation; this highlights a potential site for targeting dysregulated glycemia. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Hyperglycemia; Hypothalamus; Ventromedial nucleus
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179931
作者单位	Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Division of Endocrinology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, United States
推荐引用方式 GB/T 7714	Sutton A.K.,Goforth P.B.,Gonzalez I.E.,et al. Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal[J],2021,118(15).
APA	Sutton A.K..,Goforth P.B..,Gonzalez I.E..,Dell'Orco J..,Pei H..,...&Olson D.P..(2021).Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal.Proceedings of the National Academy of Sciences of the United States of America,118(15).
MLA	Sutton A.K.,et al."Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal".Proceedings of the National Academy of Sciences of the United States of America 118.15(2021).