气候变化领域集成服务门户(CCPortal): Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory

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DOI	10.1073/pnas.2016432118
	Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory
	Zhang Y.; Cao L.; Varga V.; Jing M.; Karadas M.; Li Y.; Buzsáki G.
发表日期	2021
ISSN	00278424
卷号	118 期号:15
英文摘要	Learning and memory are assumed to be supported by mechanisms that involve cholinergic transmission and hippocampal theta. Using G protein-coupled receptor-activation-based acetylcholine sensor (GRABACh3.0) with a fiber-photometric fluorescence readout in mice, we found that cholinergic signaling in the hippocampus increased in parallel with theta/gamma power during walking and REM sleep, while ACh3.0 signal reached a minimum during hippocampal sharp-wave ripples (SPW-R). Unexpectedly, memory performance was impaired in a hippocampus-dependent spontaneous alternation task by selective optogenetic stimulation of medial septal cholinergic neurons when the stimulation was applied in the delay area but not in the central (choice) arm of the maze. Parallel with the decreased performance, optogenetic stimulation decreased the incidence of SPW-Rs. These findings suggest that septo-hippocampal interactions play a task-phase-dependent dual role in the maintenance of memory performance, including not only theta mechanisms but also SPW-Rs. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cholinergic; Hippocampus; Sharp-wave ripples; Theta; Working memory
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179925
作者单位	Neuroscience Institute, Langone Medical Center, New York University, New York, NY 10016, United States; Department of Physics, East China Normal University, Shanghai, 200241, China; State Key Laboratory of Membrane Biology, Peking University, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, IDG, McGovern Institute for Brain Research, PKU, Beijing, 100871, China; Chinese Institute for Brain Research, Beijing, 102206, China; Department of Neurology, Langone Medical Center, New York University, New York, NY 10016, United States; Department of Neurosurgery, Langone Medical Center, New York University, New York, NY 10016, United States; Center for Neural Science, New York University, New York, NY 10003, United States
推荐引用方式 GB/T 7714	Zhang Y.,Cao L.,Varga V.,et al. Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory[J],2021,118(15).
APA	Zhang Y..,Cao L..,Varga V..,Jing M..,Karadas M..,...&Buzsáki G..(2021).Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory.Proceedings of the National Academy of Sciences of the United States of America,118(15).
MLA	Zhang Y.,et al."Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory".Proceedings of the National Academy of Sciences of the United States of America 118.15(2021).