气候变化领域集成服务门户(CCPortal): Mechanosensitive remodeling of the bacterial flagellar motor is independent of direction of rotation

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DOI	10.1073/pnas.2024608118
	Mechanosensitive remodeling of the bacterial flagellar motor is independent of direction of rotation
	Wadhwa N.; Tu Y.; Berg H.C.
发表日期	2021
ISSN	00278424
卷号	118 期号:15
英文摘要	Motility is important for the survival and dispersal of many bacteria, and it often plays a role during infections. Regulation of bacterial motility by chemical stimuli is well studied, but recent work has added a new dimension to the problem of motility control. The bidirectional flagellar motor of the bacterium Escherichia coli recruits or releases torque-generating units (stator units) in response to changes in load. Here, we show that this mechanosensitive remodeling of the flagellar motor is independent of direction of rotation. Remodeling rate constants in clockwise rotating motors and in counterclockwise rotating motors, measured previously, fall on the same curve if plotted against torque. Increased torque decreases the off rate of stator units from the motor, thereby increasing the number of active stator units at steady state. A simple mathematical model based on observed dynamics provides quantitative insight into the underlying molecular interactions. The torque-dependent remodeling mechanism represents a robust strategy to quickly regulate output (torque) in response to changes in demand (load). © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Bacterial motility; Escherichia coli; Flagellar motor; Molecular motors; Self-assembly
语种	英语
scopus关键词	Article; bacterial flagellum; bacterial strain; bacterium culture; cell function; controlled study; in vivo study; information processing; locomotion; mathematical model; mechanoreceptor; molecular dynamics; molecular interaction; priority journal; protein function; rotation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179872
作者单位	Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, United States; Rowland Institute at Harvard, Harvard University, Cambridge, MA 02142, United States; T. J. Watson Research Center, IBM, Yorktown Heights, NY 10598, United States
推荐引用方式 GB/T 7714	Wadhwa N.,Tu Y.,Berg H.C.. Mechanosensitive remodeling of the bacterial flagellar motor is independent of direction of rotation[J],2021,118(15).
APA	Wadhwa N.,Tu Y.,&Berg H.C..(2021).Mechanosensitive remodeling of the bacterial flagellar motor is independent of direction of rotation.Proceedings of the National Academy of Sciences of the United States of America,118(15).
MLA	Wadhwa N.,et al."Mechanosensitive remodeling of the bacterial flagellar motor is independent of direction of rotation".Proceedings of the National Academy of Sciences of the United States of America 118.15(2021).