气候变化领域集成服务门户(CCPortal): A neural circuit for competing approach and defense underlying prey capture

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DOI	10.1073/pnas.2013411118
	A neural circuit for competing approach and defense underlying prey capture
	Rossier D.; Franca V.L.; Salemi T.; Natale S.; Gross C.T.
发表日期	2021
ISSN	00278424
卷号	118 期号:15
英文摘要	Predators must frequently balance competing approach and defensive behaviors elicited by a moving and potentially dangerous prey. Several brain circuits supporting predation have recently been localized. However, the mechanisms by which these circuits balance the conflict between approach and defense responses remain unknown. Laboratory mice initially show alternating approach and defense responses toward cockroaches, a natural prey, but with repeated exposure become avid hunters. Here, we used in vivo neural activity recording and cell-type specific manipulations in hunting male mice to identify neurons in the lateral hypothalamus and periaqueductal gray that encode and control predatory approach and defense behaviors. We found a subset of GABAergic neurons in lateral hypothalamus that specifically encoded hunting behaviors and whose stimulation triggered predation but not feeding. This population projects to the periaqueductal gray, and stimulation of these projections promoted predation. Neurons in periaqueductal gray encoded both approach and defensive behaviors but only initially when the mouse showed high levels of fear of the prey. Our findings allow us to propose that GABAergic neurons in lateral hypothalamus facilitate predation in part by suppressing defensive responses to prey encoded in the periaqueductal gray. Our results reveal a neural circuit mechanism for controlling the balance between conflicting approach and defensive behaviors elicited by the same stimulus. © This open access article is distributed under Creative Commons Attribution-NonCommercialNoDerivatives License 4.0 (CC BY-NC-ND).
英文关键词	Aggression; LHA; PAG
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179869
作者单位	Epigenetics and Neurobiology Unit, European Molecular Biology Laboratory, Monterotondo RM, 00015, Italy; Neurobiology Master's Program, Sapienza University of Rome, Rome, 00185, Italy; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, 10691, Sweden; Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatologic Sciences, School of Medicine, University of Naples Federico II, Naples, 80131, Italy
推荐引用方式 GB/T 7714	Rossier D.,Franca V.L.,Salemi T.,et al. A neural circuit for competing approach and defense underlying prey capture[J],2021,118(15).
APA	Rossier D.,Franca V.L.,Salemi T.,Natale S.,&Gross C.T..(2021).A neural circuit for competing approach and defense underlying prey capture.Proceedings of the National Academy of Sciences of the United States of America,118(15).
MLA	Rossier D.,et al."A neural circuit for competing approach and defense underlying prey capture".Proceedings of the National Academy of Sciences of the United States of America 118.15(2021).