气候变化领域集成服务门户(CCPortal): Distinct signaling by insulin and IGF-1 receptors and their extra- And intracellular domains

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DOI	10.1073/pnas.2019474118
	Distinct signaling by insulin and IGF-1 receptors and their extra- And intracellular domains
	Nagao H.; Cai W.; Wewer Albrechtsen N.J.; Steger M.; Batista T.M.; Pan H.; Dreyfuss J.M.; Mann M.; Ronald Kahn C.
发表日期	2021
ISSN	00278424
卷号	118 期号:17
英文摘要	Insulin and insulin-like growth factor 1 (IGF-1) receptors share many downstream signaling pathways but have unique biological effects. To define the molecular signals contributing to these distinct activities, we performed global phosphoproteomics on cells expressing either insulin receptor (IR), IGF-1 receptor (IGF1R), or chimeric IR-IGF1R receptors. We show that IR preferentially stimulates phosphorylations associated with mammalian target of rapamycin complex 1 (mTORC1) and Akt pathways, whereas IGF1R preferentially stimulates phosphorylations on proteins associated with the Ras homolog family of guanosine triphosphate hydrolases (Rho GTPases), and cell cycle progression. There were also major differences in the phosphoproteome between cells expressing IR versus IGF1R in the unstimulated state, including phosphorylation of proteins involved in membrane trafficking, chromatin remodeling, and cell cycle. In cells expressing chimeric IR-IGF1R receptors, these differences in signaling could be mapped to contributions of both the extra- and intracellular domains of these receptors. Thus, despite their high homology, IR and IGF1R preferentially regulate distinct networks of phosphorylation in both the basal and stimulated states, allowing for the unique effects of these hormones on organismal function. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cellular signaling; IGF-1 signaling; Insulin signaling; Kinases; Protein phosphorylation
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179732
作者单位	Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, United States; Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY 11568, United States; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, 82152, Germany; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, 2100, Denmark; Bioinformatics and Biostatistics Core, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, United States
推荐引用方式 GB/T 7714	Nagao H.,Cai W.,Wewer Albrechtsen N.J.,et al. Distinct signaling by insulin and IGF-1 receptors and their extra- And intracellular domains[J],2021,118(17).
APA	Nagao H..,Cai W..,Wewer Albrechtsen N.J..,Steger M..,Batista T.M..,...&Ronald Kahn C..(2021).Distinct signaling by insulin and IGF-1 receptors and their extra- And intracellular domains.Proceedings of the National Academy of Sciences of the United States of America,118(17).
MLA	Nagao H.,et al."Distinct signaling by insulin and IGF-1 receptors and their extra- And intracellular domains".Proceedings of the National Academy of Sciences of the United States of America 118.17(2021).