气候变化领域集成服务门户(CCPortal): Phylogenetically diverse diets favor more complex venoms in North American pitvipers

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DOI	10.1073/pnas.2015579118
	Phylogenetically diverse diets favor more complex venoms in North American pitvipers
	Holding M.L.; Strickland J.L.; Rautsaw R.M.; Hofmann E.P.; Mason A.J.; Hogan M.P.; Nystrom G.S.; Ellsworth S.A.; Colston T.J.; Borja M.; Castañeda-Gaytán G.; Grünwald C.I.; Jones J.M.; Freitas-De-Sousa L.A.; Viala V.L.; Margres M.J.; Hingst-Zaher E.; Junqueira-De-Azevedo I.L.M.; Moura-Da-Silva A.M.; Grazziotin F.G.; Lisle Gibbs H.; Rokyta D.R.; Parkinson C.L.
发表日期	2021
ISSN	00278424
卷号	118 期号:17
英文摘要	The role of natural selection in the evolution of trait complexity can be characterized by testing hypothesized links between complex forms and their functions across species. Predatory venoms are composed of multiple proteins that collectively function to incapacitate prey. Venom complexity fluctuates over evolutionary timescales, with apparent increases and decreases in complexity, and yet the causes of this variation are unclear. We tested alternative hypotheses linking venom complexity and ecological sources of selection from diet in the largest clade of front-fanged venomous snakes in North America: the rattlesnakes, copperheads, cantils, and cottonmouths. We generated independent transcriptomic and proteomic measures of venom complexity and collated several natural history studies to quantify dietary variation. We then constructed genome-scale phylogenies for these snakes for comparative analyses. Strikingly, prey phylogenetic diversity was more strongly correlated to venom complexity than was overall prey species diversity, specifically implicating prey species’ divergence, rather than the number of lineages alone, in the evolution of complexity. Prey phylogenetic diversity further predicted transcriptomic complexity of three of the four largest gene families in viper venom, showing that complexity evolution is a concerted response among many independent gene families. We suggest that the phylogenetic diversity of prey measures functionally relevant divergence in the targets of venom, a claim supported by sequence diversity in the coagulation cascade targets of venom. Our results support the general concept that the diversity of species in an ecological community is more important than their overall number in determining evolutionary patterns in predator trait complexity. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Diet breadth; Diversity; Predator; Toxin; Transcriptomics
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179719
作者单位	Department of Biological Sciences, Clemson University, Clemson, SC 29634, United States; Department of Biological Science, Florida State University, Tallahassee, FL 32306, United States; Department of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH 43210, United States; Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango, Gómez Palacio, Dgo., C.P. 35010, Mexico; HERP.MX A.C., Villa del Álvarez, Colima, 28973, Mexico; Laboratório de Imunopatologia, Instituto Butantan, São Paulo, 05503-900, Brazil; Laboratório de Toxinologia Aplicada, Instituto Butantan, São Paulo, 05503-900, Brazil; Center of Toxins, Immune-Response and Cell Signaling, São Paulo, 05503-900, Brazil; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, United States; Museu Biológico, Instituto Butantan, São Paulo, 05503-900, Brazil; Instituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Mana...
推荐引用方式 GB/T 7714	Holding M.L.,Strickland J.L.,Rautsaw R.M.,et al. Phylogenetically diverse diets favor more complex venoms in North American pitvipers[J],2021,118(17).
APA	Holding M.L..,Strickland J.L..,Rautsaw R.M..,Hofmann E.P..,Mason A.J..,...&Parkinson C.L..(2021).Phylogenetically diverse diets favor more complex venoms in North American pitvipers.Proceedings of the National Academy of Sciences of the United States of America,118(17).
MLA	Holding M.L.,et al."Phylogenetically diverse diets favor more complex venoms in North American pitvipers".Proceedings of the National Academy of Sciences of the United States of America 118.17(2021).