气候变化领域集成服务门户(CCPortal): Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure

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DOI	10.1073/PNAS.2012533117
	Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship
	Andersson M.; Kjer H.M.; Rafael-Patino J.; Pacureanu A.; Pakkenberg B.; Thiran J.-P.; Ptito M.; Bech M.; Dahl A.B.; Dahl V.A.; Dyrby T.B.
发表日期	2021
ISSN	00278424
起始页码	33649
结束页码	33659
卷号	117 期号:52
英文摘要	Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional (3D) validation. Here, high-resolution, 3D synchrotron X-ray nano-holotomography images of white matter samples from the corpus callosum of a monkey brain reveal that blood vessels, cells, and vacuoles affect axonal diameter and trajectory. Within single axons, we find that the variation in diameter and conduction velocity correlates with the mean diameter, contesting the value of precise diameter determination in larger axons. These complex 3D axon morphologies drive previously reported 2D trends in axon diameter and g-ratio. Furthermore, we find that these morphologies bias the estimates of axon diameter with diffusion magnetic resonance imaging and, ultimately, impact the investigation and formulation of the axon structure–function relationship. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Axon morphology; Brain; Conduction velocity; MRI; Myelination
语种	英语
scopus关键词	article; axon; brain; diffusion weighted imaging; human tissue; myelination; structure activity relation; anatomy and histology; animal; axon; cell vacuole; female; Haplorhini; metabolism; myelin sheath; nuclear magnetic resonance imaging; physiology; structure activity relation; three-dimensional imaging; white matter; Animals; Axons; Female; Haplorhini; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Myelin Sheath; Structure-Activity Relationship; Vacuoles; White Matter
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179684
作者单位	Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, 2650, Denmark; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, 2800, Denmark; Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland; European Synchrotron, Grenoble, 38000, France; Research Laboratory for Stereology and Neuroscience, Copenhagen University Hospital, Bispebjerg, Copenhagen, 2400, Denmark; Radiology Department, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, 1011, Switzerland; Center for Biomedical Imaging, Lausanne, 1015, Switzerland; School of Optometry, University of Montreal, Montreal, QC H3T 1P1, Canada; Department of Neuroscience, Faculty of Health Science, University of Copenhagen, Copenhagen, 2200, Denmark; Division of Medical Radiation Physics, Department of Clinical Sciences, Lund University,...
推荐引用方式 GB/T 7714	Andersson M.,Kjer H.M.,Rafael-Patino J.,等. Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship[J],2021,117(52).
APA	Andersson M..,Kjer H.M..,Rafael-Patino J..,Pacureanu A..,Pakkenberg B..,...&Dyrby T.B..(2021).Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship.Proceedings of the National Academy of Sciences of the United States of America,117(52).
MLA	Andersson M.,et al."Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship".Proceedings of the National Academy of Sciences of the United States of America 117.52(2021).