气候变化领域集成服务门户(CCPortal): Synaptic plasticity rules with physiological calcium levels

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DOI	10.1073/PNAS.2013663117
	Synaptic plasticity rules with physiological calcium levels
	Inglebert Y.; Aljadeff J.; Brunel N.; Debanne D.
发表日期	2021
ISSN	00278424
起始页码	33639
结束页码	33648
卷号	117 期号:52
英文摘要	Spike-timing–dependent plasticity (STDP) is considered as a primary mechanism underlying formation of new memories during learning. Despite the growing interest in activity-dependent plasticity, it is still unclear whether synaptic plasticity rules inferred from in vitro experiments are correct in physiological conditions. The abnormally high calcium concentration used in in vitro studies of STDP suggests that in vivo plasticity rules may differ significantly from in vitro experiments, especially since STDP depends strongly on calcium for induction. We therefore studied here the influence of extracellular calcium on synaptic plasticity. Using a combination of experimental (patch-clamp recording and Ca2+ imaging at CA3-CA1 synapses) and theoretical approaches, we show here that the classic STDP rule in which pairs of single pre- and postsynaptic action potentials induce synaptic modifications is not valid in the physiological Ca2+ range. Rather, we found that these pairs of single stimuli are unable to induce any synaptic modification in 1.3 and 1.5 mM calcium and lead to depression in 1.8 mM. Plasticity can only be recovered when bursts of postsynaptic spikes are used, or when neurons fire at sufficiently high frequency. In conclusion, the STDP rule is profoundly altered in physiological Ca2+, but specific activity regimes restore a classical STDP profile. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Computational model; Hippocampus; Plasticity; STDP
语种	英语
scopus关键词	calcium; action potential; animal; biological model; long term potentiation; metabolism; nerve cell plasticity; nonlinear system; physiology; time factor; Wistar rat; Action Potentials; Animals; Calcium; Long-Term Potentiation; Models, Neurological; Neuronal Plasticity; Nonlinear Dynamics; Rats, Wistar; Time Factors
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179661
作者单位	Unité de Neurobiologie des canaux Ionique et de la Synapse, UMR1072, INSERM, Aix-Marseille Université, Marseille, 13015, France; Department of Neurobiology, University of Chicago, Chicago, IL 60637, United States; Department of Statistics, University of Chicago, Chicago, IL 60637, United States; Neurobiology Section, Division of Biological Sciences, University of California San Diego, San diego, CA 92093, United States; Department of Neurobiology, Duke University, Durham, NC 27710, United States; Department of Physics, Duke University, Durham, NC 27710, United States
推荐引用方式 GB/T 7714	Inglebert Y.,Aljadeff J.,Brunel N.,et al. Synaptic plasticity rules with physiological calcium levels[J],2021,117(52).
APA	Inglebert Y.,Aljadeff J.,Brunel N.,&Debanne D..(2021).Synaptic plasticity rules with physiological calcium levels.Proceedings of the National Academy of Sciences of the United States of America,117(52).
MLA	Inglebert Y.,et al."Synaptic plasticity rules with physiological calcium levels".Proceedings of the National Academy of Sciences of the United States of America 117.52(2021).