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DOI10.1073/PNAS.2005950117
Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin
Gao Y.; Chen X.; He Q.; Gimple R.C.; Liao Y.; Wang L.; Wu R.; Xie Q.; Rich J.N.; Shen K.; Yuan Z.
发表日期2021
ISSN00278424
起始页码33295
结束页码33304
卷号117期号:52
英文摘要Adipocytes have been implicated in breast tumor growth and stemness maintenance through secreted factors. However, the mechanisms by which these cytokines are regulated during diet-induced obesity and contribute to breast tumorigenesis remain largely unknown. Here we show that transcription cofactor TAZ in adipocytes is directly up-regulated by the free fatty acid/PPARγ axis upon dietary fat stimulation. TAZ knockdown alters the expression profile of a series of secreted proteins and attenuates the tumor-supporting function of adipocytes. Moreover, we identify Resistin, an adipose-derived hormone, as a functional downstream target of TAZ, which facilitates tumorigenesis, and its expression correlated with adipocyitc TAZ in triple-negative breast cancer samples. Further, Adiponectin-cre–mediated TAZ knockout in adipocytes mitigates breast tumor growth. Taken together, our findings highlight how diet-induced TAZ expression in adipocytes promotes tumorigenesis, suggesting promising cancer therapeutic targets. © 2020 National Academy of Sciences. All rights reserved.
英文关键词Adipocyte; Breast tumorigenesis; Resistin; TAZ
语种英语
scopus关键词fatty acid; peroxisome proliferator activated receptor gamma; resistin; transactivator protein; WWTR1 protein, human; Wwtr1 protein, mouse; adipocyte; animal; breast tumor; C57BL mouse; cancer stem cell; carcinogenesis; cell proliferation; diet; female; gene expression regulation; genetics; human; metabolism; obesity; pathology; triple negative breast cancer; Adipocytes; Adiposity; Animals; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Diet; Fatty Acids; Female; Gene Expression Regulation, Neoplastic; Humans; Mice, Inbred C57BL; Neoplastic Stem Cells; Obesity; PPAR gamma; Resistin; Trans-Activators; Triple Negative Breast Neoplasms
来源期刊Proceedings of the National Academy of Sciences of the United States of America
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/179652
作者单位Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China; Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Department of Biochemistry and Molecular and Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, San diego, CA 92037, United States; Department of Pathology, Case Western Reserve University, Cleveland, OH 44120, United States; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, 100101, China; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China; Department of Neurosciences, University of California, San Diego, School of Medicine, San diego, CA 92037, United States
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GB/T 7714
Gao Y.,Chen X.,He Q.,et al. Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin[J],2021,117(52).
APA Gao Y..,Chen X..,He Q..,Gimple R.C..,Liao Y..,...&Yuan Z..(2021).Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin.Proceedings of the National Academy of Sciences of the United States of America,117(52).
MLA Gao Y.,et al."Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin".Proceedings of the National Academy of Sciences of the United States of America 117.52(2021).
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