气候变化领域集成服务门户(CCPortal): AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes

CCPortal

DOI	10.1073/PNAS.2001976117
	AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes
	Yang C.; Yin L.; Xie F.; Ma M.; Huang S.; Zeng Y.; Shen W.-H.; Dong A.; Li L.
发表日期	2021
ISSN	00278424
起始页码	33679
结束页码	33688
卷号	117 期号:52
英文摘要	Photomorphogenesis is a critical developmental process bridging light-regulated transcriptional reprogramming with morphological changes in organisms. Strikingly, the chromatin-based transcriptional control of photomorphogenesis remains poorly understood. Here, we show that the Arabidopsis (Arabidopsis thaliana) ortholog of ATP-dependent chromatin-remodeling factor AtINO80 represses plant photomorphogenesis. Loss of AtINO80 inhibited hypocotyl cell elongation and caused anthocyanin accumulation. Both light-induced genes and dark-induced genes were affected in the atino80 mutant. Genome-wide occupancy of the H2A.Z histone variant and levels of histone H3 were reduced in atino80. In particular, AtINO80 bound the gene body of ELONGATED HYPOCOTYL 5 (HY5), resulting in lower chromatin incorporations of H2A.Z and H3 at HY5 in atino80. Genetic analysis revealed that AtINO80 acts in a phytochrome B- and HY5-dependent manner in the regulation of photomorphogenesis. Together, our study elucidates a mechanism wherein AtINO80 modulates nucleosome density and H2A.Z incorporation and represses the transcription of light-related genes, such as HY5, to fine tune plant photomorphogenesis. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	AtINO80; H2A.Z; Nucleosome; Photomorphogenesis; Transcription
语种	英语
scopus关键词	histone H2AZ; histone H3; transcriptome; Arabidopsis protein; H2A.Z protein, Arabidopsis; histone; transcriptome; Arabidopsis thaliana; Article; AtINO80 gene; cell density; chromatin; controlled study; gene control; gene expression; gene function; gene repression; genetic transcription and translation; HY5 gene; nonhuman; nucleosome; overlapping gene; photomorphogenesis; plant gene; priority journal; quantitative analysis; real time polymerase chain reaction; Arabidopsis; darkness; gene expression regulation; genetics; light; metabolism; morphogenesis; mutation; nucleosome; plant gene; radiation response; Arabidopsis; Arabidopsis Proteins; Darkness; Gene Expression Regulation, Plant; Genes, Plant; Histones; Light; Morphogenesis; Mutation; Nucleosomes; Transcriptome
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179642
作者单位	State Key Laboratory of Genetic Engineering and Institute of Plant Biology, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China; Institut de Biologie Moléculaire des Plantes, CNRS, Université de Strasbourg, Strasbourg, 67084, France
推荐引用方式 GB/T 7714	Yang C.,Yin L.,Xie F.,et al. AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes[J],2021,117(52).
APA	Yang C..,Yin L..,Xie F..,Ma M..,Huang S..,...&Li L..(2021).AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes.Proceedings of the National Academy of Sciences of the United States of America,117(52).
MLA	Yang C.,et al."AtINO80 represses photomorphogenesis by modulating nucleosome density and H2A.Z incorporation in light-related genes".Proceedings of the National Academy of Sciences of the United States of America 117.52(2021).