气候变化领域集成服务门户(CCPortal): Poststroke acute dysexecutive syndrome, a disorder resulting from minor stroke due to disruption of network dynamics

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DOI	10.1073/PNAS.2013231117
	Poststroke acute dysexecutive syndrome, a disorder resulting from minor stroke due to disruption of network dynamics
	Marsh E.B.; Brodbeck C.; Llinas R.H.; Mallick D.; Kulasingham J.P.; Simon J.Z.; Llinás R.R.
发表日期	2021
ISSN	00278424
起始页码	33578
结束页码	33585
卷号	117 期号:52
英文摘要	Stroke patients with small central nervous system infarcts often demonstrate an acute dysexecutive syndrome characterized by difficulty with attention, concentration, and processing speed, independent of lesion size or location. We use magnetoencephalography (MEG) to show that disruption of network dynamics may be responsible. Nine patients with recent minor strokes and eight age-similar controls underwent cognitive screening using the Montreal cognitive assessment (MoCA) and MEG to evaluate differences in cerebral activation patterns. During MEG, subjects participated in a visual picture–word matching task. Task complexity was increased as testing progressed. Cluster-based permutation tests determined differences in activation patterns within the visual cortex, fusiform gyrus, and lateral temporal lobe. At visit 1, MoCA scores were significantly lower for patients than controls (median [interquartile range] = 26.0 [4] versus 29.5 [3], P = 0.005), and patient reaction times were increased. The amplitude of activation was significantly lower after infarct and demonstrated a pattern of temporal dispersion independent of stroke location. Differences were prominent in the fusiform gyrus and lateral temporal lobe. The pattern suggests that distributed network dysfunction may be responsible. Additionally, controls were able to modulate their cerebral activity based on task difficulty. In contrast, stroke patients exhibited the same low-amplitude response to all stimuli. Group differences remained, to a lesser degree, 6 mo later; while MoCA scores and reaction times improved for patients. This study suggests that function is a globally distributed property beyond area-specific functionality and illustrates the need for longer-term follow-up studies to determine whether abnormal activation patterns ultimately resolve or another mechanism underlies continued recovery. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Magnetoencephalography; Recovery; Stroke
语种	英语
scopus关键词	accuracy; adult; aged; Article; attention disturbance; brain function; brain infarction; cerebrovascular accident; clinical article; cognitive defect; concentration loss; controlled study; diffusion weighted imaging; dispersion; event related potential; female; follow up; fusiform gyrus; human; language processing; longitudinal study; magnetoencephalography; male; mental task; Montreal cognitive assessment; nerve cell network; network dynamics; occipital lobe; poststroke acute dysexecutive syndrome; priority journal; processing speed; reaction time; temporal lobe; visual cortex; visual memory; acute disease; adolescent; behavior; brain mapping; cerebrovascular accident; diagnostic imaging; middle aged; nerve cell network; nuclear magnetic resonance imaging; pathophysiology; syndrome; task performance; time factor; young adult; Acute Disease; Adolescent; Adult; Aged; Behavior; Brain Mapping; Female; Humans; Magnetic Resonance Imaging; Magnetoencephalography; Male; Middle Aged; Nerve Net; Stroke; Syndrome; Task Performance and Analysis; Time Factors; Young Adult
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179617
作者单位	Department of Neurology, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, United States; Institute for Systems Research, University of Maryland, College Park, MD 20740, United States; Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20740, United States; Department of Biology, University of Maryland, College Park, MD 20740, United States; Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY 10016, United States
推荐引用方式 GB/T 7714	Marsh E.B.,Brodbeck C.,Llinas R.H.,et al. Poststroke acute dysexecutive syndrome, a disorder resulting from minor stroke due to disruption of network dynamics[J],2021,117(52).
APA	Marsh E.B..,Brodbeck C..,Llinas R.H..,Mallick D..,Kulasingham J.P..,...&Llinás R.R..(2021).Poststroke acute dysexecutive syndrome, a disorder resulting from minor stroke due to disruption of network dynamics.Proceedings of the National Academy of Sciences of the United States of America,117(52).
MLA	Marsh E.B.,et al."Poststroke acute dysexecutive syndrome, a disorder resulting from minor stroke due to disruption of network dynamics".Proceedings of the National Academy of Sciences of the United States of America 117.52(2021).