气候变化领域集成服务门户(CCPortal): Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot

CCPortal

DOI	10.1073/PNAS.2011297117
	Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot
	Li Z.; Zhu L.; Sun H.; Shen Y.; Hu D.; Wu W.; Wang Y.; Qian C.; Sun M.
发表日期	2021
ISSN	00278424
起始页码	32962
结束页码	32969
卷号	117 期号:52
英文摘要	Clinical investigations have shown that a nonimmunogenic “cold” tumor is usually accompanied by few immunopositive cells and more immunosuppressive cells in the tumor microenvironment (TME), which is still the bottleneck of immune activation. Here, a fluorine assembly nanocluster was explored to break the shackles of immunosuppression, reawaken the immune system, and turn the cold tumor “hot.” Once under laser irradiation, FS@PMPt produces sufficient reactive oxygen species (ROS) to fracture the ROS-sensitive linker, thus releasing the cisplatin conjugated PMPt to penetrate into the tumors and kill the regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Meanwhile, ROS will induce potent immunogenic cell death (ICD) and further promote the accumulation of dendritic cells (DCs) and T cells, therefore not only increasing the infiltration of immunopositive cells from the outside but also reducing the immunosuppressive cells from the inside to break through the bottleneck of immune activation. The FS@PMPt nanocluster regulates the immune process in TME from negative to positive, from shallow to deep, to turn the cold tumor into a hot tumor and provoke a robust antitumor immune response. © 2020 National Academy of Sciences. All rights reserved.
英文关键词	Cold tumor; Immunogenic cell death; Immunosuppressive tumor microenvironment; Nanocluster; Photodynamic immunotherapy
语种	英语
scopus关键词	antineoplastic agent; dendrimer; fluorine; immunologic factor; nanoconjugate; PAMAM Starburst; platinum; reactive oxygen metabolite; animal; Bagg albino mouse; chemistry; dendritic cell; drug effect; female; immunology; metabolism; mouse; myeloid-derived suppressor cell; regulatory T lymphocyte; synthesis; tumor cell line; tumor microenvironment; Animals; Antineoplastic Agents; Cell Line, Tumor; Dendrimers; Dendritic Cells; Female; Fluorine; Immunologic Factors; Mice; Mice, Inbred BALB C; Myeloid-Derived Suppressor Cells; Nanoconjugates; Platinum; Reactive Oxygen Species; T-Lymphocytes, Regulatory; Tumor Microenvironment
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/179613
作者单位	State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China
推荐引用方式 GB/T 7714	Li Z.,Zhu L.,Sun H.,et al. Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot[J],2021,117(52).
APA	Li Z..,Zhu L..,Sun H..,Shen Y..,Hu D..,...&Sun M..(2021).Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot.Proceedings of the National Academy of Sciences of the United States of America,117(52).
MLA	Li Z.,et al."Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot".Proceedings of the National Academy of Sciences of the United States of America 117.52(2021).