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DOI	10.1016/j.ultsonch.2020.105008
	Sonochemical synthesis of novel thermo-responsive polymer and tungsten dioxide composite for the temperature-controlled reversible “on-off” electrochemical detection of β-Blocker metoprolol
	Mutharani B.; Ranganathan P.; Chen S.-M.; Chen T.-W.; Ali M.A.; Mahmoud A.H.
发表日期	2020
ISSN	13504177
卷号	64
英文摘要	Thermo-responsive polymer nanocomposite based on poly (styrene-co-N-isopropylacrylamide) hybrid tungsten dioxide (WO2@PS-co-PNIPAM) was synthesized by a facile ultrasonic irradiation (Frequency; 20 kHz, power; 180 W, calorimetrically determined power; 5.73 W in the bath, and Type; probe) method in the presence of water as inisolv. The as-synthesized WO2@PS-co-PNIPAM modified glassy carbon electrode (WO2@PS-co-PNIPAM/GCE) was acting as a reversibly switched detection for the electrooxidation of metoprolol (MTP), with the thermal stimuli response of the PNIPAM. In below lower critical solution temperature (LCST), the PS-co-PNIPAM expanded to embed the electroactive sites of WO2, and the MTP could not proceed via the polymer to attain electronic transfer, indicating the “off” state. Rather, in above LCST, the PS-co-PNIPAM shrank to reveal electroactive sites and expand cyclic voltammetric background peak currents, the MTP was capable to undergo electro-oxidation reaction usually and produce the response current, indicating “on” state. Additionally, the proposed sensor had excellent sensitivity (2.21 µA µM−1 cm−2), wide dynamic range (0.05–306 µM), and a low limit of detection of 0.03 µM for MTP. Intriguingly, the fabricated sensor demonstrates the good selectivity towards the detection of MTP among the possible interfering compounds. Eventually, the WO2@PS-co-PNIPAM/GCE has been utilized in the analysis of MTP in human blood serum samples. © 2020 Elsevier B.V.
英文关键词	Metoprolol; Reversible behavior; Sonochemical green method; Switched detection; WO2@PS-co-PNIPAM
scopus关键词	Acrylic monomers; Amides; Electrooxidation; Glass membrane electrodes; Nanocomposites; Polymers; Sonochemistry; Styrene; Tungsten compounds; Ultrasonic applications; Electro-oxidation reaction; ELectrochemical detection; Green method; Lower critical solution temperature; Metoprolol; Modified glassy carbon electrode; Reversible behavior; WO2@PS-co-PNIPAM; Chemical detection; aciclovir; carbon; ferricyanide; ibuprofen; methotrexate; metoprolol; naproxen; oxygen; polymer; theophylline; tungsten; aeration; Article; calorimetry; chemical structure; conductance; cross linking; cyclic voltammetry; differential pulse voltammetry; electrochemical detection; electron transport; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; high temperature; limit of detection; low temperature; oxidation; pH; polymerization; priority journal; protonation and deprotonation; synthesis; temperature sensitivity; ultrasound; X ray diffraction; X ray photoemission spectroscopy
来源期刊	Ultrasonics Sonochemistry
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/176900
作者单位	Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, China; Research and Development Center for Smart Textile Technology, National Taipei University of Technology, Taipei, China; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia; Department of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia
推荐引用方式 GB/T 7714	Mutharani B.,Ranganathan P.,Chen S.-M.,等. Sonochemical synthesis of novel thermo-responsive polymer and tungsten dioxide composite for the temperature-controlled reversible “on-off” electrochemical detection of β-Blocker metoprolol[J],2020,64.
APA	Mutharani B.,Ranganathan P.,Chen S.-M.,Chen T.-W.,Ali M.A.,&Mahmoud A.H..(2020).Sonochemical synthesis of novel thermo-responsive polymer and tungsten dioxide composite for the temperature-controlled reversible “on-off” electrochemical detection of β-Blocker metoprolol.Ultrasonics Sonochemistry,64.
MLA	Mutharani B.,et al."Sonochemical synthesis of novel thermo-responsive polymer and tungsten dioxide composite for the temperature-controlled reversible “on-off” electrochemical detection of β-Blocker metoprolol".Ultrasonics Sonochemistry 64(2020).